Karatas, Mert OlgunAlici, BulentCakir, UmitCetinkaya, EnginDemir, DuduErgun, AdemGencer, Nahit2024-08-042024-08-0420142169-14012169-141Xhttps://doi.org/10.3109/21691401.2013.794352https://hdl.handle.net/11616/96452In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 mu m M for hCA I and 88 m M for hCA II) performed higher inhibitory activity than others.eninfo:eu-repo/semantics/openAccessbenzimidazoliumcarbonic anhydrasecoumarinimidazoliuminhibitionArticle4231921982365667110.3109/21691401.2013.7943522-s2.0-84901012639Q1WOS:000336498100006Q4