Browsing Tıbbi Biyoloji ve Genetik Anabilim Dalı by Author "190238"

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Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes

Demir, Ayşe Banu; Koç, Ahmet (Biochemical and Biophysical Research Communications, 2010)

The free radical theory of aging states that oxidative damage to biomolecules causes aging and that antioxidants neutralize free radicals and thus decelerate aging. Mitochondria produce most of the reactive oxygen species, ...
Identification of respiratory chain gene mutations that shorten replicative life span in yeast

Hacıoğlu, Elise; Demir, Ayşe Banu; Koç, Ahmet (Experimental Gerontology, 2012)

Aging is the progressive accumulation of alterations in cells that elevates the risk of death. The mitochondrial theory of aging postulates that free radicals produced by the mitochondrial respiratory system contribute ...
High copy overexpression screening reveals pdr5 as the main doxorubicin resistance gene in yeast

Demir, Ayşe Banu; Koç, Ahmet (PLoS One, 2015)

Doxorubicin is one of the most potent anticancer drugs used in the treatment of various cancer types. The efficacy of doxorubicin is influenced by the drug resistance mechanisms and its cytotoxicity. In this study, we ...

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