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Yayın tarihi için Tıbbi Biyoloji ve Genetik Anabilim Dalı listeleme

Toplam kayıt 64, listelenen: 1-20

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Leishmania major Promastigot hücrelerine karşı makrofajlardan nitrojen radikali ve tümör nekroz faktörü salgılanması

Aybay, Cemalettin; İmir, Turgut; Kayhan, Çağlar; Kayhan, Başak (İnfeksiyon Dergisi, 1996)
İnsan serumunun leishmania major promastigot hücreleri üzerine öldürücü etkisi

Aybay, Cemalettin; Çağlar, Kayhan; İmir, Turgut; Kayhan, Başak (Türkiye Parazitoloji Dergisi, 1997)
The comparison of the effect of somatostatin and SMS 201 995 on enzyme change following endoscopic retrograde cholangiopancreotography

Görgül, Ahmet; Kayhan, Burçak; Menteş, Bülent; Kayhan, Başak; Akı, Zeynep (Gazi MEdical Journal, 1998)
A competitive enzyme linked immunosorbent assay ELISA for determination of human albumin in the nanogram range

Aybay, Cemalettin; İmir, Turgut; Kayhan, Başak (Gazi Medical Journal, 1999)
Fare makrofajlarından nitrik oksit sentezine interferon gamma ve lipopolisakkaritin etkileri

Tayşi, Bülent; Kayhan, Başak; Aybay, Cemalettin; İmir, Turgut (Türkiye Tıp Dergisi, 1999)

Nitrik oksit (NO) makrofajların sitotoksik etkisinin ortaya çıkmasında rol almaktadır. NO’in yapımını nitrik oksit sentaz (NOS) enzimi katalize etmektedir. Sitozolde bulunan bu enzimin, enzimi kodlayan genler, hücre veya ...
The combined use of dimethyl sulfoxide with chemotherapeutics on bladder cell culture

Sözen, Sinan; Yaman, Önder; Oğuzülgen, İbrahim; Kayhan, Başak; Tuncel, Aytuğ; Alkibay, Turgut; Bozkırlı, İbrahim (Gazi Medical Journal, 2001)
Selenoprotein R is a zinc containing stereo specific methionine sulfoxide reductase

Kryukov, Gregory V.; Kumar, R. Abhilash; Koç, Ahmet; Sun, Zhaohui; Gladyshev, Vadim N. (Proc Natl Acad Sci U S A., 2002)

Selenoprotein R (SelR) is a mammalian selenocysteine-containing protein with no known function. Here we report that cysteine homologs of SelR are present in all organisms except certain parasites and hyperthermophiles, ...
Reaction mechanism evolutionary analysis and role of zinc in Drosophila methionine R sulfoxide reductase

Kumar, R. Abhilash; Koç, Ahmet; Cerny, Ronald L.; Gladyshev, Vadim N. (J Biol Chem, 2002)

Methionine residues in proteins are susceptible to oxidation, and the resulting methionine sulfoxides can be reduced back to methionines by methionine-S-sulfoxide reductase (MsrA) and methionine-R-sulfoxide reductase (MsrB). ...
Effect of mucosal immunomodulation with fed cholera toxin on healing of experimental colonic anastomosis

Kaplan, Mehmet; Menteş, Bülent; Tatlıcıoğlu, Ertan; Kayhan, Başak; Aybay, Cemalettin (Diseases of the Colon & Rectum, 2002)

The aim of this study was to investigate in rats whether preoperative orogastric administration of low doses of cholera toxin would influence the mechanical strength of experimental colonic anastomosis on the basis of ...
Replication independent MCB gene induction and deoxyribonucleotide accumulation at G1 S in Saccharomyces cerevisiae

Koç, Ahmet; Wheeler, Linda J.; Mathews, Christopher K.; Merrill, Gary F. (J Biol Chem, 2003)

In Saccharomyces cerevisiae, many genes encoding enzymes involved in deoxyribonucleotide synthesis are expressed preferentially near the G1/S boundary of the cell cycle. The relationship between the induction ...
Raw 264.7 makrofaj hücrelerinden lipopolisakkarid aracılığı ile nitrik oksid salgılanmasına monofosforil lipid A nın etkisi

Aybay, Cemalettin; İmir, Turgut; Gülsayın, Cengiz; Kayhan, Başak (Flora, 2003)

Lipopolisakkaridin (LPS veya endotoksin) toksik etkilerinden lipid A kısmı sorumludur. Lipid A’nın yapısal analogları ve öncül moleküllerinin tanımlanmasından sonra bunların LPS’nin biyolojik etkilerine karflı ...
Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools

Koç, Ahmet; Wheeler, Linda J.; Mathews, Christopher K. (J Biol Chem, 2003)

The relationship between dNTP levels and DNA synthesis was investigated using factor-synchronized yeast treated with the ribonucleotide reductase inhibitor hydroxyurea (HU). Although HU blocked DNA synthesis and ...
Glatiramer acetate Copaxone regulates nitric oxide and related cytokine secretion in experimental autoimmune encephalomyelitis

Kayhan, Başak; Aharoni, Rina; Arnon, Ruth (Immunology Letters, 2003)

Nitric oxide (NO) is an important mediator involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). We examined the effect of glatiramer acetate (GA), an agent with ...
Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species dependent and independent components of aging

Koç, Ahmet; Gasch, Audrey P.; Rutherford, Julian C.; Kim, Hwa-Young; Gladyshev, Vadim N. (Proc Natl Acad Sci. USA., 2004)

Aging is thought to be caused by the accumulation of damage, primarily from oxidative modifications of cellular components by reactive oxygen species (ROS). Here we used yeast methionine sulfoxide reductases MsrA and ...
Can IL 2R alpha be a valuable marker along with CA 19 9 in the diagnosis of chronic pancreatitis and pancreatic cancer

Kayhan, Başak; Kayhan, Burçak; Akdoğan, Meral (International journal of biological markers, 2004)

Pancreatic cancer is characterized initially by non-specific abdominal symptoms followed by rapid tumor progression. Although chronic pancreatitis is a benign disorder, it can be one of the causative factors of pancreatic ...
Secretion of brain derived neurotrophic factor BDNF interleukin 10 and transforming growth factor beta by glatiramer acetate specific T cells in the brain

Aharoni, Rina; Kayhan, Başak; Sela, Michael; Arnon, Ruth (Neurology, 2004)
A DNA aptamer prevents influenza infection by blocking the receptor binding region of the viral hemagglutinin

Jeon, Sung Ho; Kayhan, Başak; Benyedidia, Tamar; Arnon, Ruth (Journal of Biological Chemistry, 2004)

Influenza A virus infection is a major source of morbidity and mortality worldwide. Current means of control for influenza are based on prophylaxis by vaccines and on treatment by the available specific influenza neuraminidase ...
Infection of dendritic cells by a gamma 2 herpesvirus induces functional modulation

Flano, Emillio; Kayhan, Başak; Woodland, David; Blackman, Marcia (Journal of immunology, 2005)

The murine γ-herpesvirus-68 (γHV68) establishes viral latency in dendritic cells (DCs). In the present study, we examined the specific consequences of DC infection by γHV68, both in vivo and in vitro. Ex vivo analysis ...
Therapeutic effect of the immunomodulator glatiramer acetate on trinitrobenzene sulfonic acid induced experimental colitis

Aharoni, Rina; Kayhan, Başak; Arnon, Ruth (Inflammatory Bowel Diseases, 2005)

Inflammatory bowel diseases are characterized by detrimental immune reactivity in the gut and imbalance between proinflammatory and antiinflammatory reactivity. In an attempt to downregulate inflammatory bowel disease, we ...
Single or multiple perforations with varying locations as a complication of intestinal Behçet s disease report of three cases

Işık, Burak; Ara, Cengiz; Kırımlıoğlu, Vedat; Söğütlü, Gökhan; Yılmaz, Sezai; Kırımlıoğlu, Hale (Scandinavian Journal of Gastroenterology, 2005; 40: 599 / 603., 2005)

Intestinal ulcers in Behc¸et’s disease (BD) tend to cause perforation with significant morbidity. The optimal surgical procedure in such cases is controversial and the postoperative period can be eventful with an unpredictable ...

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