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Gönderi tarihi için Tıbbi Biyoloji ve Genetik Anabilim Dalı listeleme

Gönderi tarihi için Tıbbi Biyoloji ve Genetik Anabilim Dalı listeleme

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  • Thioredoxin is required for deoxyribonucleotide pool maintenance during S phase 
    Koç, Ahmet; Mathews, Christopher K.; Wheeler, Linda J.; Gross, Michael K.; Merrill, Gary F. (J Biol Chem, 2006)
    Thioredoxin was initially identified by its ability to serve as an electron donor for ribonucleotide reductase in vitro. Whether it serves a similar function in vivo is unclear. In Saccharomyces cerevisiae, it was ...
  • Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species dependent and independent components of aging 
    Koç, Ahmet; Gasch, Audrey P.; Rutherford, Julian C.; Kim, Hwa-Young; Gladyshev, Vadim N. (Proc Natl Acad Sci. USA., 2004)
    Aging is thought to be caused by the accumulation of damage, primarily from oxidative modifications of cellular components by reactive oxygen species (ROS). Here we used yeast methionine sulfoxide reductases MsrA and ...
  • Replication independent MCB gene induction and deoxyribonucleotide accumulation at G1 S in Saccharomyces cerevisiae 
    Koç, Ahmet; Wheeler, Linda J.; Mathews, Christopher K.; Merrill, Gary F. (J Biol Chem, 2003)
    In Saccharomyces cerevisiae, many genes encoding enzymes involved in deoxyribonucleotide synthesis are expressed preferentially near the G1/S boundary of the cell cycle. The relationship between the induction ...
  • Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools 
    Koç, Ahmet; Wheeler, Linda J.; Mathews, Christopher K. (J Biol Chem, 2003)
    The relationship between dNTP levels and DNA synthesis was investigated using factor-synchronized yeast treated with the ribonucleotide reductase inhibitor hydroxyurea (HU). Although HU blocked DNA synthesis and ...
  • Reaction mechanism evolutionary analysis and role of zinc in Drosophila methionine R sulfoxide reductase 
    Kumar, R. Abhilash; Koç, Ahmet; Cerny, Ronald L.; Gladyshev, Vadim N. (J Biol Chem, 2002)
    Methionine residues in proteins are susceptible to oxidation, and the resulting methionine sulfoxides can be reduced back to methionines by methionine-S-sulfoxide reductase (MsrA) and methionine-R-sulfoxide reductase (MsrB). ...
  • Selenoprotein R is a zinc containing stereo specific methionine sulfoxide reductase 
    Kryukov, Gregory V.; Kumar, R. Abhilash; Koç, Ahmet; Sun, Zhaohui; Gladyshev, Vadim N. (Proc Natl Acad Sci U S A., 2002)
    Selenoprotein R (SelR) is a mammalian selenocysteine-containing protein with no known function. Here we report that cysteine homologs of SelR are present in all organisms except certain parasites and hyperthermophiles, ...
  • Solid organ transplant alıcılarında transplantasyon öncesi hazırlık ve tanı 
    Kayhan, Başak (Türkiye Klinikleri Enfeksiyon Hastalıkları, 2017)
    Solid organ transplantasyonu (SOT) öncesi alıcı ve vericide bazı immünolojik testlerin yapılması zorunluluktur. Bunlar alıcı ve verici arasındaki doku uyuşmazlıklarının araştırıldığı immünogenetik testler ve immünolojik ...
  • The effect of exercise induced weight loss on myokines and adipokines in overweight sedentary females steps aerobics vs jogging walking exercises 
    Düzova, Halil; Güllü, Esin; Çiçek, Güner; Köksal, Burcu; Kayhan, Başak; Güllü, Abdullah; Şahin, İbrahim (J Sports Med Phys Fitness, 2016)
    The objectives of this study were to verify effects of step-aerobic exercise (SAE) and jogging-walking exercise (JWE) program on myokines and adipokines levels in overweight sedentary females. METHODS:Volunteer subjects ...
  • Mystery of immune response in relapsed brucellosis immunophenotyping and multiple cytokine analysis 
    Kayhan, Başak; Kayabaş, Üner; Kölgelier, Servet; Otlu, Barış; Gül, Mehmet; Kurtoğlu, Elçin Latıfe; Bayındır, Yaşar (Mediterrenean Journal of Infection Microbes and Antimicrobials, 2016)
    Introduction: Brucella spp. are intracellular bacteria that may cause acute, subacute and chronic infections. Although optimum antibiotic treatment is available, relapse of brucellosis occurs in some patients. There ...
  • Merkezi sinir sisteminde immün yanıt 
    Kayhan, Başak; Gül, Mehmet (Türkiye Klinikleri Nöroşirürji, 2016)
    İmmun yanıt konağın kendisine yabancı bir makromolekul ve mikroorganizma ile karşılaşma sonrası gosterdiği reaksiyon/lardır. İmmun yanıt, doğal ve kazanılmış immun yanıt olmak uzere iki şekilde gercekleşir. İmmun sistem ...
  • Histological and biochemical effects of dexmedetomidine on liver during an inflammatory bowel isease 
    Gül, Mehmet; Kayhan, Başak; Elbe, Hülya; Doğan, Zümrüt; Otlu, Ali (Ultrastructural Pathology, 2015)
    Inflammation in the liver is an extraintestinal manifestation that is frequently seen during inflammatory bowel diseases (IBD). The authors investigated histopathologycal, ultrastructural and antioxidant effects ...
  • Histopathological ultrastructural and apoptotic changes in diabetic rat placenta 
    Gül, Mehmet; Bostancıeri, Nuray; Çetin, Aslı; Kepekçi, Remziye Aysun; Şimşek, Ömer Yavuz; Kayhan, Başak; Turhan, Uğur; Otlu, Ali (Balkan Medical Journal, 2015)
    The exchange of substances between mother and fetus via the placenta plays a vital role during development. A number of developmental disorders in the fetus and placenta are observed during diabetic pregnancies. Diabetes, ...
  • Immune response in the liver under conditions of infection malignancy and transplantation 
    Kayhan, Başak; Özdamar, Şükrü Oğuz; Padberg, Winfried; Kayabaş, Üner; Aharoni, Rina; Mirshahidi, Saied (Clinical and developmental immunology, 2014)
    The liver is the largest solid organ in the body and commands a large blood supply that is rich in bacterial products, environment toxins, and food antigens, which are repeatedly scanned by cells within the liver. In ...
  • Fc dependent monoclonal IgG1 mediated suppression of antibody response 
    Kayhan, Başak; Aybay, Cemalettin (İmmunological İnvestigations, 2014)
    It has been known for a long time that passively administered antibodies (Abs) or immune complexes regulate the immune response to their specific antigen (Ag). IgG may sometimes suppress the humoral immune response against ...
  • Dexmedetomidine ameliorates TNBS induced colitis by inducing immunomodulator effect 
    Erdoğan Kayhan, Gülay; Gül, Mehmet; Kayhan, Başak; Gedik, Ender; Özgül, Ülkü; Kurtoğlu, Elçin Latıfe; Durmuş, Mahmut; Ersoy, Mehmet Özcan (Journal of Surgical Research, 2013)
    Background: Since sedatives are often administered to immune-compromised and critically ill patients, our understanding of immunomodulation by sedation will be critical. Dexmedetomidine, a selective a2-adrenergic receptor ...
  • Aptamers an in vitro evolution of therapeutic and diagnostic applications in medicine 
    Kayhan, Başak; Kayabaş, Üner (Disease and Molecular Medicine, 2013)
    Aptamers are nucleic acid oligomers with distinct conformational shapes that allow binding targets with high affinity and specificity. Selective Evolution of Ligands by Exponential Enrichment (SELEX); an in vitro selection ...
  • A kidney transplant centers Initial experiences in eastern Turkey 
    Pişkin, Turgut; Ünal, Bülent; Koz, Süleyman; Ulutaş, Oğuz; Yağmur, Jülide; Kayhan, Başak; Taşkapan, Hülya; Şahin, İdris; Baysal, Tamer (Transplantation Proceedings, 2012)
    Objectives. Kidney transplantation is the best treatment method associated with improved quality of life and better survival for patients with end-stage renal disease. We started performing kidney transplantations in ...
  • The effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitis 
    Aktunç, Erol; Kayhan, Başak; Araslı, Mehmet; Doğan Gün, Banu; Barut, Figen (Immunopharmacology and Immunotoxicology, 2011)
    Inflammatory bowel diseases are characterized by disabilities in gastrointestinal system and defects in mucosal immune system. Statins are 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitor and are used to treat ...
  • Tüberkülozda korunma ve bağışıklık 
    Bayındır, Yaşar; Kayhan, Başak (Türkiye Klinikleri, 2011)
    Çok eski çağlardan beri bilinen tüberküloz, Mycobacterium tuberculosis'in neden olduğu bulaşıcı bir enfeksiyon hastalığıdır. 1980'li yıllardan itibaren dünya genelinde görülme sıklığındaki artış, korunma ve kontrol önlemlerini ...
  • Otoimmünitede genetik duyarlılık 
    Kayhan, Başak (Türkiye Klinikleri, 2011)
    Otoimmün hastalıklarda tanısal yaklaşımlar çoğu zaman geniş bir hastalık yelpazesine adres olabilmekte, bu nedenle de tedaviye yönelik yaklaşımlar, sadece hastalığın klinik belirtileri ile kısıtlanabilmektedir. Genetik ...