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Konu "Aging" için Tıbbi Biyoloji ve Genetik Anabilim Dalı listeleme

Konu "Aging" için Tıbbi Biyoloji ve Genetik Anabilim Dalı listeleme

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  • Effects of deleting mitochondrial Antioxidant genes on life span 
    Ünlü, Ercan Selçuk; Koç, Ahmet (Ann N Y Acad Sci., 2007)
    Reactive oxygen species (ROS) damage biomolecules, accelerate aging, and shorten life span, whereas antioxidant enzymes mitigate these effects. Because mitochondria are a primary site of ROS generation and also a primary ...
  • Methionine sulfoxide reduction and the aging process 
    Koç, Ahmet; Gladyshev, Vadim N. (Ann N Y Acad Sci., 2007)
    Aging has been described for multicellular and asymmetri-cally dividing organisms, but the mechanisms are poorly understood. Ox-idation of proteins is considered to be one of the major factors that leadsto aging. Oxidative ...
  • The roles of thiol oxidoreductases in yeast replicative aging 
    Hacıoğlu, Elise; Esmer, Işıl; Fomenko, Dmitri E.; Gladyshev, Vadim N.; Koç, Ahmet (Mechanisms of Ageing and Development, 2010)
    Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox ...
  • Identification of respiratory chain gene mutations that shorten replicative life span in yeast 
    Hacıoğlu, Elise; Demir, Ayşe Banu; Koç, Ahmet (Experimental Gerontology, 2012)
    Aging is the progressive accumulation of alterations in cells that elevates the risk of death. The mitochondrial theory of aging postulates that free radicals produced by the mitochondrial respiratory system contribute ...
  • Absence of superoxide dismutase activity causes nuclear DNA fragmentation during the aging process 
    Muid, Khandaker Ashfaqul; Karakaya, Hüseyin Çağlar; Koç, Ahmet (Biochemical and Biophysical Research Communications, 2014)
    Superoxide dismutases (SOD) serve as an important antioxidant defense mechanism in aerobic organisms, and deletion of these genes shortens the replicative life span in the budding yeast Saccharomyces cerevisiae. Even ...