Tıbbi Biyoloji ve Genetik Anabilim Dalı: Recent submissions

Now showing items 21-40 of 64

Analysis of peripheral blood lymphocyte phenotypes and Th1 Th2 cytokines profile in the systemic immune responses ofHelicobacter pylori infected individuals

Kayhan, Başak; Araslı, Mehmet; Eren, Hacı; Aydemir, Selim; Aktaş, Elif (Microbiology and Immunology, 2008)

H. pylori elicits specific humoral and cellularimmune responsesin themucosalimmune system.However, the type and extent of T lymphocyte response in the systemic immune system is not clear for H. pylori positive patients. ...
Otoimmünitede genetik duyarlılık

Kayhan, Başak (Türkiye Klinikleri, 2011)

Otoimmün hastalıklarda tanısal yaklaşımlar çoğu zaman geniş bir hastalık yelpazesine adres olabilmekte, bu nedenle de tedaviye yönelik yaklaşımlar, sadece hastalığın klinik belirtileri ile kısıtlanabilmektedir. Genetik ...
Tüberkülozda korunma ve bağışıklık

Bayındır, Yaşar; Kayhan, Başak (Türkiye Klinikleri, 2011)

Çok eski çağlardan beri bilinen tüberküloz, Mycobacterium tuberculosis'in neden olduğu bulaşıcı bir enfeksiyon hastalığıdır. 1980'li yıllardan itibaren dünya genelinde görülme sıklığındaki artış, korunma ve kontrol önlemlerini ...
A DNA aptamer prevents influenza infection by blocking the receptor binding region of the viral hemagglutinin

Jeon, Sung Ho; Kayhan, Başak; Benyedidia, Tamar; Arnon, Ruth (Journal of Biological Chemistry, 2004)

Influenza A virus infection is a major source of morbidity and mortality worldwide. Current means of control for influenza are based on prophylaxis by vaccines and on treatment by the available specific influenza neuraminidase ...
Infection of dendritic cells by a gamma 2 herpesvirus induces functional modulation

Flano, Emillio; Kayhan, Başak; Woodland, David; Blackman, Marcia (Journal of immunology, 2005)

The murine γ-herpesvirus-68 (γHV68) establishes viral latency in dendritic cells (DCs). In the present study, we examined the specific consequences of DC infection by γHV68, both in vivo and in vitro. Ex vivo analysis ...
Serum pankreatik elastaz 1 acil servislerde akut ankreatit tanısı için güvenilir bir yöntem olabilir mi?

Kayhan, Başak; Kayhan, Burçak; Özaslan, Ersan; Özer, Diğdem (Akademik Gastroenteroloji Dergisi, 2006)

Acil servise karın ağrısı ile başvuran hastaların bir kısmında, rutin radyolojik ve laboratuvar testleri ile akut pankreatit teşhis edilememektedir. Bu çalışmada, akut pankreatit tanısında serum elastazın duyarlılığı ...
The effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitis

Aktunç, Erol; Kayhan, Başak; Araslı, Mehmet; Doğan Gün, Banu; Barut, Figen (Immunopharmacology and Immunotoxicology, 2011)

Inflammatory bowel diseases are characterized by disabilities in gastrointestinal system and defects in mucosal immune system. Statins are 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitor and are used to treat ...
A kidney transplant centers Initial experiences in eastern Turkey

Pişkin, Turgut; Ünal, Bülent; Koz, Süleyman; Ulutaş, Oğuz; Yağmur, Jülide; Kayhan, Başak; Taşkapan, Hülya; Şahin, İdris; Baysal, Tamer (Transplantation Proceedings, 2012)

Objectives. Kidney transplantation is the best treatment method associated with improved quality of life and better survival for patients with end-stage renal disease. We started performing kidney transplantations in ...
Aptamers an in vitro evolution of therapeutic and diagnostic applications in medicine

Kayhan, Başak; Kayabaş, Üner (Disease and Molecular Medicine, 2013)

Aptamers are nucleic acid oligomers with distinct conformational shapes that allow binding targets with high affinity and specificity. Selective Evolution of Ligands by Exponential Enrichment (SELEX); an in vitro selection ...
Dexmedetomidine ameliorates TNBS induced colitis by inducing immunomodulator effect

Erdoğan Kayhan, Gülay; Gül, Mehmet; Kayhan, Başak; Gedik, Ender; Özgül, Ülkü; Kurtoğlu, Elçin Latıfe; Durmuş, Mahmut; Ersoy, Mehmet Özcan (Journal of Surgical Research, 2013)

Background: Since sedatives are often administered to immune-compromised and critically ill patients, our understanding of immunomodulation by sedation will be critical. Dexmedetomidine, a selective a2-adrenergic receptor ...
Fc dependent monoclonal IgG1 mediated suppression of antibody response

Kayhan, Başak; Aybay, Cemalettin (İmmunological İnvestigations, 2014)

It has been known for a long time that passively administered antibodies (Abs) or immune complexes regulate the immune response to their specific antigen (Ag). IgG may sometimes suppress the humoral immune response against ...
Immune response in the liver under conditions of infection malignancy and transplantation

Kayhan, Başak; Özdamar, Şükrü Oğuz; Padberg, Winfried; Kayabaş, Üner; Aharoni, Rina; Mirshahidi, Saied (Clinical and developmental immunology, 2014)

The liver is the largest solid organ in the body and commands a large blood supply that is rich in bacterial products, environment toxins, and food antigens, which are repeatedly scanned by cells within the liver. In ...
Histopathological ultrastructural and apoptotic changes in diabetic rat placenta

Gül, Mehmet; Bostancıeri, Nuray; Çetin, Aslı; Kepekçi, Remziye Aysun; Şimşek, Ömer Yavuz; Kayhan, Başak; Turhan, Uğur; Otlu, Ali (Balkan Medical Journal, 2015)

The exchange of substances between mother and fetus via the placenta plays a vital role during development. A number of developmental disorders in the fetus and placenta are observed during diabetic pregnancies. Diabetes, ...
Histological and biochemical effects of dexmedetomidine on liver during an inflammatory bowel isease

Gül, Mehmet; Kayhan, Başak; Elbe, Hülya; Doğan, Zümrüt; Otlu, Ali (Ultrastructural Pathology, 2015)

Inflammation in the liver is an extraintestinal manifestation that is frequently seen during inflammatory bowel diseases (IBD). The authors investigated histopathologycal, ultrastructural and antioxidant effects ...
Merkezi sinir sisteminde immün yanıt

Kayhan, Başak; Gül, Mehmet (Türkiye Klinikleri Nöroşirürji, 2016)

İmmun yanıt konağın kendisine yabancı bir makromolekul ve mikroorganizma ile karşılaşma sonrası gosterdiği reaksiyon/lardır. İmmun yanıt, doğal ve kazanılmış immun yanıt olmak uzere iki şekilde gercekleşir. İmmun sistem ...
Mystery of immune response in relapsed brucellosis immunophenotyping and multiple cytokine analysis

Kayhan, Başak; Kayabaş, Üner; Kölgelier, Servet; Otlu, Barış; Gül, Mehmet; Kurtoğlu, Elçin Latıfe; Bayındır, Yaşar (Mediterrenean Journal of Infection Microbes and Antimicrobials, 2016)

Introduction: Brucella spp. are intracellular bacteria that may cause acute, subacute and chronic infections. Although optimum antibiotic treatment is available, relapse of brucellosis occurs in some patients. There ...
The effect of exercise induced weight loss on myokines and adipokines in overweight sedentary females steps aerobics vs jogging walking exercises

Düzova, Halil; Güllü, Esin; Çiçek, Güner; Köksal, Burcu; Kayhan, Başak; Güllü, Abdullah; Şahin, İbrahim (J Sports Med Phys Fitness, 2016)

The objectives of this study were to verify effects of step-aerobic exercise (SAE) and jogging-walking exercise (JWE) program on myokines and adipokines levels in overweight sedentary females. METHODS:Volunteer subjects ...
Solid organ transplant alıcılarında transplantasyon öncesi hazırlık ve tanı

Kayhan, Başak (Türkiye Klinikleri Enfeksiyon Hastalıkları, 2017)

Solid organ transplantasyonu (SOT) öncesi alıcı ve vericide bazı immünolojik testlerin yapılması zorunluluktur. Bunlar alıcı ve verici arasındaki doku uyuşmazlıklarının araştırıldığı immünogenetik testler ve immünolojik ...
Selenoprotein R is a zinc containing stereo specific methionine sulfoxide reductase

Kryukov, Gregory V.; Kumar, R. Abhilash; Koç, Ahmet; Sun, Zhaohui; Gladyshev, Vadim N. (Proc Natl Acad Sci U S A., 2002)

Selenoprotein R (SelR) is a mammalian selenocysteine-containing protein with no known function. Here we report that cysteine homologs of SelR are present in all organisms except certain parasites and hyperthermophiles, ...
Reaction mechanism evolutionary analysis and role of zinc in Drosophila methionine R sulfoxide reductase

Kumar, R. Abhilash; Koç, Ahmet; Cerny, Ronald L.; Gladyshev, Vadim N. (J Biol Chem, 2002)

Methionine residues in proteins are susceptible to oxidation, and the resulting methionine sulfoxides can be reduced back to methionines by methionine-S-sulfoxide reductase (MsrA) and methionine-R-sulfoxide reductase (MsrB). ...

Now showing items 21-40 of 64

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