Serum ß2-Mikroglobülin: Preeklampsinin Erken Tahminindeki Önemi

Abstract

Bu çalisma ikinci trimester maternal serum ß2-mikroglobülin düzeylerinin preeklampsi gelisiminin önceden saptanmasindaki prediktif degerini arastirmak için planlandi. Materyal Metod: Onsekiz ve 26. gestasyonel haftalar arasinda gebeligi bulunan 7 nullipar ve 8 multipar olmak üzere toplam 15 normotansif hastanin maternal serum ß2-mikroglobülin düzeyleri nefelometrik olarak saptandi. Hastalar gebelikleri terme ulasana kadar aylik olarak takip edildi. Yapilan takiplerinde preeklampsi gelisenler ile gelismeyenlerin maternal serum ß2- mikroglobülin düzeyleri karsilastirildi. Bulgular: On bes hastanin ortalama maternal serum ß2-mikroglobülin düzeyleri 1.00±0.10 mg /L olarak saptandi. Bu hastalarin yapilan takiplerinde sadece 2 hastada preeklampsi gelisirken (%13.3), 13 hasta normotansif olarak kaldi (%86.7). Preeklampsi gelisen 2 hastanin maternal serum ß2-mikroglobülin düzeyleri ile preeklampsi gelismeyen 13 hastanin maternal serum ß2-mikroglobülin düzeyleri arasinda herhangi bir fark bulunamadi (1.01±0.10mg/L, 1.00±0.11 mg/L, p<0.02). Sonuç: Bu çalismada ikinci trimester serum ß2-mikroglobülin düzeyleri preeklampsi gelisiminin önceden tanisinda kullanilabilecek güvenilir bir marker olarak bulunmamistir. Ancak serum ß2-mikroglobülin düzeylerinin preeklamptik hastalardaki etki ve rolünü kesin olarak açiklamak için daha ileri in vivo ve in vitro çalismalara ihtiyaç vardir.

The study was planned to determine whether or not, second trimester maternal serum levels of ß2- microglobulin could be used to predict subsequent devolopment of preeclampsia. Study design: Serum ß2-microglobulin levels of 7 nulliparous and 8 multiparous women with normotensive were determined nephelometrically. Blood samples were collected between 18 and 26 weeks gestation and those cases were followed up prospectively for subsequent devolopment of preeclampsia. Results: Mean maternal serum ß2-microglobulin levels of 15 normotensive pregnant patients were found 1.00±0.10 mg /L. Fifteen normotensive women were followed up prospectively, two of them (13.3%) preeclampsia developed and 13 women remained normotensive (86.7%) throughout pregnancy. No difference betw een maternal serum ß2- microglobulin levels of two patients with preeclampsia and 13 patients who remained normotensive during gestation was found (1.01±0.10mg/L vs 1.00±0.11 mg/L, p<0.02). Conclusion: Second trimester maternal serum ß2-microglobulin levels can not be used as an predictive marker of subsequent preeclampsia. But, further in vivo and in vitro studies are needed to exactly clarify the effects and the role of serum ß2-microglobulin levels in patients with preeclampsia.