Öz:Amaç: Bu çal??mada ?izofreni hastalar?nda psikotik belirtilerin alevlenme döneminde dikkat ve bellek i?levlerdegözlenen bozulman?n, belirtilerdeki gerilemeye paralelolarak düzelme gösterece?i hipotezi test edilmi?tir.Gereç ve Yöntem:Ara?t?rman?n verileri Kas?m 2003-Ocak2005 tarihleri aras?nda ?nönü Üniversitesi T?p FakültesiTurgut Özal T?p Merkezinde toplanm??t?r. Psikiyatri servisve poliklini?inde ayaktan ve/veya yatarak takip ve tedaviedilmekte olan, DSM-IV tan? ölçütlerine göre ?izofrenibozuklu?u tan?s? alan ve tümü antipsikotik ilaç kullanmakta olan, 18-50 ya?lar? aras?nda 27 hasta çal??mayaal?nm??t?r. Hastalara belirtilerin alevli oldu?u dönemdeK?sa Psikiyatrik De?erlendirme Ölçe?i (BPRS), PozitifSemptomlar? De?erlendirme Ölçe?i (SAPS), NegatifSemptomlar? De?erlendirme Ölçe?i (SANS), Yan EtkiDerecelendirme Ölçe?i (UKU) uygulanm??, ayn? günWechsler Bellek Ölçe?i (WMS-R), Stroop testi ve SözelBellek Süreçleri Testi (SBST) yap?lm??t?r. Ayn? uygulamahastalar?n belirtileri belirgin derecede geriledi?inde(BPRS puanlar?nda en az %50 azalma oldu?unda) tekrarlanm??t?r. ?ki dönemde uygulanan testler WilcoxonSigned Ranks Test ile kar??la?t?r?lm??t?r. Bulgular:Hastal???n belirtilerinin yat??t??? dönemde WMS-Rtestinde ki?isel aktüel bilgi, yönelim, konsantrasyon,mant?ksal bellek ve dikkat puanlar? ile SBST de uzun vek?sa süreli bellek puanlar? alevli dönemdekine göreanlaml? düzeyde daha yüksek; tüm Stroop alt test puanlar? daha dü?ük bulunmu?tur. Sonuç: ?izofreni bozuklu?unda belirtilerin artt??? dönemde gözlenen dikkat vebellek i?levlerindeki bozulma, belirtilerin yat??mas? ilegeriye dönebilmektedir. Bu gözlem ?izofreni hastalar?ndaki bili?sel y?k?m?n azalmas? aç?s?ndan alevlenmelerinönlenmesinin önemini ortaya koymaktad?r
Abstract:Objective: In this study, we proposed that if schizophrenic symptoms will decrease with drug treatment, itwould be improvement in attention and memory functions. Method: This research has been done in InonuUniversity Turgut Ozal Medicine Center Psychiatry Clinicbetween 2003- 2005. We included 27 patients whoseages ranged between 18-50 and who were inpatientsand/or outpatients of Psychiatry Clinic, treated with thediagnosis of schizophrenia according to DSM-IV diagnosis criteria. During their acute periods Brief PsychiatricRating Scale (BPRS), Positive Symptoms Rating Scale(SAPS), Negative Symptoms Rating Scale (SANS) andUKU Side Affect Assessment Inquiry were applied topatients and, at the same day they were also givenWechsler Memory Scale (WMS-R), Stroop Test and aVerbal Test of Memory Process (SBST). Same procedureswere repeated when their symptoms improvement(when their BPRS scores were reduced at least %50). Byusing Wilcoxon Signed Ranks Test, we compared psychometric measures that were performed in patients in twoperiods. Results: When the results of neuropsychologicaltests in the acute and symptom resolution periods werecompared, in WMS-R test; personal and current information task, orientation, concentration, logical memoryand attention scores, in SBST; long and short periodmemory scores were found significantly higher, and allStroop subtest scores were found significantly lower inthe response to treatment. Conclusion: In our study, wefound that schizophrenia patients have better attentionand memory functions when positive and negativesymptoms were regressed. This observation supports theimportance of prevention of exacerbations in terms ofreduction cognitive deteriorations in patients with schi zophrenia.
