Abstract:
Aim: Smoking remains a global problem and it is known as a cause of many diseases. Globally, tobacco use is the most important
cause of preventable morbidity and mortality. The aim of this study is to evaluate the impact of smoking on insulin parameters and
inflammatory markers, and the variation of these parameters according to the duration of smoking cessation in patients who quit
smoking.
Material and Methods: 612 patients aged 18-70 years (n = 612) who were undergoing treatment and follow-up for type 2 diabetes
mellitus were included in this study. The patients were categorized into 3 groups (i.e., smokers, ex-smokers, and nonsmokers).
Test results ofof hemoglobin A1c (HbA1c), cholesterol, triglyceride, high density lipoprotein (HDL) levels, low density lipoprotein,
leukocyte count, C-reactive protein, fibrinogen, and ferritin levels were obtained. Body mass indexes (BMI) and blood pressure were
also measured.
Results: Smoking was significantly associated with the male gender, HbA1c, HDL level, BMI, waist circumference, the homeostatic
model assessment-insulin resistance (HOMA-IR) core, and inflammatory markers. Current smokers who smoked ≥20 packs/year
demonstrated poorer metabolic results compared to those who smoked 0-10 pack(s)/year. The metabolic parameters were worse in
ex-smokers who quit smoking <1 year ago compared to ex-smokers who quit 1-5 years, 5-10 years, and >10 years ago.
Conclusion: We demonstrated that smoking increased insulin resistance, metabolic syndrome, and inflammation. Smoking was also
observed to worsen glycemic control by further increasing insulin resistance in diabetic patients.
