Özet:
Aim: We investigated the effects of nevirapine on changes in body weight, lipid peroxidation/antioxidant status, apoptotic markers
and neuromorphology following monosodium glutamate-induced neurotoxicity in prepubertal mice.
Material and Methods: Eighty male mice which were randomly divided into eight groups of ten mice each (n=10) were used. Mice
in each group were administered oral vehicle, monosodium glutamate (MSG) at 2g/kg, or one of three doses of nevirapine (at 7.5,
15 and 30 mg/kg) alone or co-administered with MSG. Vehicle or nevirapine were administered daily for 28 days, while MSG was
administered on days 1-7. On day 28, animals were euthanized and blood was collected for estimation of plasma malondialdehyde
(MDA) and antioxidant levels; while sections of the cerebrum and hippocampus were either fixed and processed for general histology,
or homogenized for the estimation of brain biochemical parameters.
Results: Results showed that administration of nevirapine alone (or when co-administered with MSG) was associated with a
reduction in weight gain, increase in plasma/brain MDA levels, morphologic/morphometric evidence of dose-related hypercellularity;
and varying degrees of neuroprotection, with co-administration. Nitric oxide levels and caspase-3 activity increased only with MSG,
while superoxide dismutase activity decreased.
Conclusions: In conclusion, subchronic administration of nevirapine was associated with dose-related alterations of the measured
parameters; indicating possible neuroprotection and mitigation of MSG neurotoxicity at some of the doses studied.
