Abstract:
Aim: To investigate whether the neutrophil lymphocyte ratio is a determining factor in the detection of complicated acute calculous
cholecystitis.
Material and Methods: The study was planned as retrospective and multi-centered. One hundred and twenty patients were divided
into 3 groups equally. Group1; patients with symptomatic gall stones having undergone elective cholecystectomy. Group 2; patients
having undergone cholecystectomy with acute cholecystitis.Group 3: patients having undergone cholecystectomy with acute
complicated cholecystitis. Blood glucose, C-reactive protein, leukocyte, neutrophil, and lymphocyte ratio were recorded from the
hospital records in the final laboratory parameters of patients before surgery. ROC nalysis, sensitivity, specificity, positive predictive
value (PPV), negative predictive value (NPV), cut-off and AUC values for NLR were calculated.
Results: There was a significant difference between the gangrenous cholecystitis group and other groups in terms of white blood cell
count values (p = 0.002 and p <0.001).There was a significant difference between the gangrenous cholecystitis group and other groups
in terms of CRP values (p <0.001).There was a difference between gangrenous cholecystitis group and normal cholecystectomy
group according to the mean glucose values (p = 0.006)According to ROC analysis, sensitivity, specificity, cut-off and AUC values for
NLR in terms of gangrenous cholecystitis and acute cholecystitis were,77.50%,67.5%,80.9%,73.8%,6.56 and 0.736, respectively. For
gangrenous cholecystitis group and normal cholecystectomy group; these values were 85%, 77.5%, 94%, 87.9%, 4.43% and 0.878%,
respectively.
Conclusion: The increase in the acute cholecystitis N / L ratio appears to be a simple inflammatory marker that indicates that the
condition has become complicated, that is easily detectable and does not add additional cost.
