Abstract:
Aim: In recent years, neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR) and mean platelet volume (MPV) has
been shown to be important indicators of systemicinflammation. Studies have shown that NLR and PLR are higher and that MPV is
lower in lichen planus patients compared to the control group. In this study, NLR, PLR and MPV values of lichen planus patients were
calculated and investigated whether these parameters were related to nail and oral mucosal involvement.
Material and Methods: Eighty one patients with lichen planus without any systemic, infectious and autoimmune disease were
included in this study while 81 patients who were admitted to the outpatient clinic for any non-inflammatory condition and whom
had blood picture were included in the study as control group.
Results: There was no statistically significant difference between neutrophil count, lymphocyte count, leukocyte count, platelet
count, NLR and PLR values in LP patients and control group (p> 0.05). MPV value of LP patients had a mean of 8.10 ± 1.40 , and
controls had a mean of 7.21 ± 1.45, and the difference was statistically significant (p <0.001). There wasn’t statistically significant
relationship between neutrophil count, lymphocyte count, leukocyte count, platelet count, NLR, PLR and MPV values and nail and
oral mucosa involvement (p> 0.05).
Conclusion: It can be concluded that NLR and PLR were not suitable parameters to show inflammation in LP. The significant higher
values of MPV in LP patients suggests that it may be used as a better marker of inflammation in LP patients than NLR and PLR.
Nevertheless, the lack of significant association of MPV with nail involvement and oral mucosal involvement may restrict clinical
use of it in LP.
