Abstract:
Aim: Postoperative pelvic adhesions (PPAs) are a common complication that leads to many problems. This study aimed to compare
the role of Seprafilm (a protective barrier), and molsidomine (MOL), recognized for its antioxidative and antiproliferative effects, in
preventing pelvic adhesion.
Material and Methods: A total of 30 of female Wistar albino rats were randomly divided into 3 groups. They underwent bilateral
uterine horn injury. The rats in the Sham group (n=10) received no special treatment. The rats in the Seprafilm group (n=10) were
treated withSeprafilm. The rats in the MOL group (n=10) received 10 mg/kg MOL orally for 14 days. Adhesion scores were evaluated
using macroscopic, microscopic, and immunohistochemical grading 14 days postoperatively.
Results:The Majuzi adhesion score of the rats in the MOL group [1 (0-4)] was lower than the score of the rats in the sham [4 (2-5)]
and Seprafilm [4 (1-5)] (p<0.05). The glutathione peroxidase level in the MOL group [9.34 (5.45 - 19.82)] was higher than that in the
sham [7.05 (2.67 – 8.9)] and Seprafilm [5.85 (3.92 - 22.55)] groups (p<0.05).
Conclusions: This study showed that MOL reduced the formation of PPAs in a rat uterine horn model.The need for larger studies is
an obvious need to elucidate this issue.
