Abstract:
Aim: The objective of this study was to evaluate the correlation of inflammation, oxidant and antioxidant biomarkers with the stages
of CKD.
It is well known that inflammation has an important role in CKD. While PON-1 and PAF-AH are biomarkers with antioxidant
characteristics, MDA is an oxidant biomarker.
Material and Methods: The participants were divided into 3 groups. Control (n=37) group, non-hemodialysis chronic kidney disease
(non-HD CKD) group and hemodialysis group (n=40) . One hudred twenty-one participants were included in this cross-sectional and
observational study. Serum PON-1, PAF-AH, MDA levels were measured.
Results: There was a significant difference between the groups regarding the median MDRD values (p<0.001). The median MDRD
value in the control, non-HD CKD and dialysis groups was 93. 36 and 7 respectively. There was also a significant difference between
the groups regarding the median PON-1 value (p<0.001). The median PON-1 value in the control, predialysis and dialysis groups
was 67, 63.1 and 62 respectively. There was also no significant difference between the groups regarding the median PAF-AH value
(p=0.469). The median PAF-AH value in the control, predialysis and dialysis groups was 115.7, 116.95 and 117.4 respectively. There
was also a significant difference between the groups regarding the median MDA value (p<0.001).
Conclusion: We concluded that PON-1 and MDA might be considered as useful biomarkers in CKD patients. The correlation between
PAF-AH and CKD, larger subject sizes are needed. We believe that our study will be a starting point for larger studies focused on CKD
severity and antioxidant/oxidant biomarkers.
