Abstract:
Aim: To compare the anterior segment parameters and specular microscopy findings between patients with Rheumatoid arthritis
(RA) and healthy controls.
Material and Methods: In this prospective study, 55 patients diagnosed with RA and age and matched 55 control subjects without any
systemic diseases were enrolled. Central corneal thickness (CCT), corneal endothelial cell density (cells/mm2) (ECD), percentage of
hexagonal cells of corneal endothelial cells ( HEX), and cell size variability (CV%) of endothelial cells were measured using noncontact
specular microscopy (CEM-530 Specular Mıcroscope, NIDEK ).
Anterior chamber depth (ACD), Axial Length (AL), white to white limbus length and keratometry were measured using an ocular
biometry system. In all patients of RA group, disease activity severity was assessed with The Disease Activity Score in 28 joints
diseases activity score (DAS28 rate).
Results: There were statistically significant differences between RA patients and control subjects regarding ACD (3.06±0.43 vs
3.24±0.31; p: 0.001), white to white limbus length (11.63±0.45 vs 11.76±0.38; p: 0.02), CV% (35.49±5.96 vs 32.02±5.22, p: 0.001)
and hexagonality (67.31±4.66 vs 71.35±11.02; p: 0.001). In correlation analysis, there was a negative correlation between disease
periods and both ACD and CCT; while there was a negative correlation with the number of cells and endothelial cell density and DAS
28 score.
Conclusion: Although there was not a significant difference regarding endothelial cell density values in RA group compared with
healthy controls; there was a negative correlation between the disease activity and endothelial cell density. Moreover, CV% was
significantly higher and hexagonality % was significantly lower in RA group; indicating the endothelial damage and increase in the
expected compensatory response.
Further, larger studies are warranted to define the exact pathological mechanisms and clinical outcomes of this corneal endothelial
damage in RA patients.
