The use of wire cerclage after sternal closure is the standard method because of its rigidity and strength. Despite this, they have many disadvantages such as tissue trauma, operatorinduced failures, and the risk of infection. To avoid complications during sternotomy and promote tissue regeneration, tissue adhesives should be used in post-surgical treatment. Here, we report a highly biocompatible, biomimetic, biodegradable, antibacterial, and UV-curable polyurethane-acrylate (PU-A) tissue adhesive for sternal closure as a supportive to wire cerclage. In the study, PU-As were synthesized with variable biocompatible monomers, such as silk sericin, polyethylene glycol, dopamine, and an aliphatic isocyanate 4,4'-methylenebis(cyclohexyl isocyanate). The highest adhesion strength was found to be 4322 kPa, and the ex vivo compressive test result was determined as 715 kPa. The adhesive was determined to be highly biocompatible (on L929 cells), biodegradable, and antibacterial (on Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus bacteria). Finally, after opening the sternum of rats, the adhesive was applied to bond the bones and cured with UV for 5 min. According to the results, there was no visible inflammation in the adhesive groups, while some animals had high inflammation in the cyanoacrylate and wire cerclage groups. These results indicate that the adhesive may be suitable for sternal fixation by preventing the disadvantages of the steel wires and promoting tissue healing.
C1 [Balcioglu, Sevgi] Sakarya Univ Appl Sci, Dept Med Lab, TR-54000 Sakarya, Turkey.
[Noma, Samir Abbas Ali] Bursa Uludag Univ, Fac Arts & Sci, Dept Chem, TR-16059 Bursa, Turkey.
[Ulu, Ahmet; Koytepe, Suleyman; Ates, Burhan] Inonu Univ, Fac Arts & Sci, Dept Chem, TR-44210 Malatya, Turkey.
[Karaaslan-Tunc, Merve Goksin] Selcuk Univ, Taskent Vocat Sch, TR-42000 Konya, Turkey.
[Ozhan, Onural; Parlakpinar, Hakan] Inonu Univ, Med Fac, Dept Med Pharmacol, TR-44210 Malatya, Turkey.
[Vardi, Nigar] Inonu Univ, Med Fac, Dept Histol & Embryol, TR-44210 Malatya, Turkey.
[Colak, Mehmet Cengiz] Inonuu Univ, Med Fac, Dept Cardiovasc Surg, TR-44210 Malatya, Turkey.