Özet:
Circadian rhythm is defined as rhythmic fluctuations in physiological
processes which enable living organisms to make necessary
arrangements for upcoming changes in the environment thereby
optimizing their metabolism. Mammalian circadian clock consists
of feedback(negative) and feedforward (positive) loops consisting of
transcription, translation and posttranslational events. It is believed
that there are two kinds of clock functioning in the body.The master
clock residing in hypothalamus oscillating in conjunction with light/
dark cycle whereas peripheral clocks occur in peripheral tissues and
influenced by other environmental factors such as feeding. The
rhythmic alterations in activities of metabolic pathways are provided
by the coordinated expressions of clock genes and consequently by
clock-controlled genes. The current studies indicate that consumption
of food at inappropriate times as well as sleep restrictions lead
to metabolic dysfunctions due to disruption of circadian rhythm
which result in diabetes, obesity and heart diseases. To this end, it is
aimed, in this review, to examine interactions among food or sleep,
metabolism and circadian rhythm with an insight into metabolomic
profiling studies of circadian disturbances by sleep restrictions
following an overview of working mechanisms of circadian rhythms
in mammals.
