dc.contributor.author |
Baykalır, Burcu Gül |
|
dc.contributor.author |
Çiftçi, Osman |
|
dc.contributor.author |
Çetin, Aslı |
|
dc.contributor.author |
Öztanır, Mustafa Namık |
|
dc.contributor.author |
Başak, Neşe |
|
dc.date.accessioned |
2017-04-14T10:30:43Z |
|
dc.date.available |
2017-04-14T10:30:43Z |
|
dc.date.issued |
2016 |
|
dc.identifier.citation |
Baykalır, B. G. Çiftçi, O. Çetin, A. Öztanır, M. N. Başak, N. (2016). The protective cardiac effects of myrcene after global cerebral ıschemia reperfusion in C57BL J6 mouse . Acta Cir Bras., 456-462. |
tr_TR |
dc.identifier.uri |
http://dx.doi.org/10.1590/S0102-865020160070000005 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/6668 |
|
dc.description.abstract |
ABSTRACT
PURPOSE: To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused
global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice.
METHODS: Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR+IR. The control group
was received 0.1% carboxymethyl cellulose as a vehicle following a medial incision without carotid occlusion. In the IR group, the
bilateral carotid arteries were clipped for 15min, and treated with the vehicle intraperitoneally(ip) for 10 days. MYR (200mg/kg) was
received dissolved in 0.1%CMC for 10 days. In the MYR+IR group, the IR model was applied exactly as in the IR group, and then they
were treated with MYR 10 days.
RESULTS: The cerebral IR caused oxidative damage (increase TBARS, decrease antioxidant parameters). Treatment of MYR was
increased in GSH,GPx,CAT,SOD activity while TBARS level was decreased. In addition, degenerative changes in I/R group heart tissue
were ameliorated by MYR administration.
CONCLUSİON: The administration of β-myrcene protects oxidative and histological damage in the heart tissue after global ischemiareperfusion
and may be useful safe alternative treatment for cardiac tissue after ischemic stroke. |
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dc.language.iso |
eng |
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dc.publisher |
Acta cir bras |
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dc.relation.isversionof |
DOI: 10.1590/S0102-865020160070000005 |
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dc.rights |
info:eu-repo/semantics/openAccess |
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dc.subject |
Brain Ischemia |
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dc.subject |
Reperfusion |
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dc.subject |
Oxidative Stress |
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dc.subject |
Mice |
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dc.title |
The protective cardiac effects of myrcene after global cerebral ıschemia reperfusion in C57BL J6 mouse |
tr_TR |
dc.type |
article |
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dc.relation.journal |
Acta cir bras |
tr_TR |
dc.contributor.department |
İnönü Üniversitesi |
tr_TR |
dc.contributor.authorID |
TR58659 |
tr_TR |
dc.contributor.authorID |
TR102040 |
tr_TR |
dc.contributor.authorID |
TR52354 |
tr_TR |
dc.contributor.authorID |
TR107942 |
tr_TR |
dc.contributor.authorID |
TR103979 |
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dc.identifier.volume |
31 |
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dc.identifier.issue |
7 |
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dc.identifier.startpage |
456 |
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dc.identifier.endpage |
462 |
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