Abstract:
In the present study, the beneficial effect of hesperidin (HP), a citrus flavonoid, on cisplatin (CP)-induced
neurotoxicity was investigated. A total of 28 rats were equally divided into four groups; the first group was kept
as control. In the second and third groups, CP and HP were given at the doses of 7 and 50 mg/kg/day,
respectively. In the fourth group, CP and HP were given together at the same doses. The results indicated that
although CP caused significant induction of lipid peroxidations and reduction in the antioxidant defense system
potency in the brain and sciatic nerve, HP prevented these effects of CP. Besides, CP led to histopathological
damage, mainly apoptosis, as well as electromyographical (EMG) changes in sciatic nerve. On the other hand,
HP treatment reversed histopathological and EMG effects of CP. In conclusion, CP had severe dose-limiting
neurotoxic effects and these effects of CP can be prevented by HP treatment. Thus, it appears that coadministration
of HP with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.
