Abstract:
Aims: A functional maturational delay in the central nervous system is dwelled upon in the pathogenesis
of monosymptomatic nocturnal enuresis (MNE). In this study we studied whether according
to controls N200 and P300, components of the event-related potential (ERP), which is related to
aspects of cognitive processing, showed any di¡erence in its topographic distribution in children
within the age group 10 ^13 with monosymptomatic nocturnal enuresis and discussed its relation
to the pathogenesis of MNE. Methods: We performed P300 in 18 patients with MNE and in
16 age-matched healthy subjects. P300 were evoked by an auditory oddball paradigm consisting of
150 tone bursts (80% 1 kHz; 20% 2 kHz). The latencies of the N200 and the P300 waves and the
amplitude of the P300 wave were measured. Results: There was no statistical di¡erence between
the enuretic group and the controls in N200 and P300 latency and amplitude in the midline frontal
(Fz), central (Cz), and parietal (Pz) recording site of the 10 ^ 20 International System. In the enuretic
group while P300 amplitude in the Fz site was signi¢cantly less than the P300 amplitude in the Cz
site, there was no statistical di¡erence between the Fz and Pz P300 amplitude values. Conclusions:
When di¡erent levels of maturational delay are considered in MNE, it may be claimed that maturational
delay in children whose enuresis lasts until older ages will be di¡erent from those whose
enuresis ends at an early age. The determination of P300 amplitude in parietal records being less
in enuretics when compared to the controls may show that there are regional di¡erences in stimuli
processing rate/quality. Neurourol. Urodynam.
