Abstract:
Objectives. This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced
ototoxicity.
Methods. To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of
oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione
peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult
female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp
(CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output
functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood
samples were taken.
Results. In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and
12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly
changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was
seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal
values, similar to the K group. No significant differences were detected in the either D or K group’s measurements.
Conclusion. According to these results, Dxp may prevent cisplatin-induced ototoxicity.
