Abstract:
This experimental study was designed to
investigate the protective effects of molsidomine (MOL)
on against cisplatin-induced ototoxicity (CIO). To examine
this effect, distortion product otoacoustic emissions
(DPOAEs) measurements and serum levels of oxidative
and antioxidant status [including malondialdehyde (MDA),
superoxide dismutase (SOD), catalase (CAT), glutathione
(GSH), glutathione peroxidase (GPX), total oxidant status
(TOS), total antioxidant status (TAS), and oxidative stress
index (OSI)] were evaluated. Thirty-two female wistar
albino rats were divided into four groups including; control
(Group K), cisplatin (Group C), cisplatin plus MOL group
(Group CM), and MOL group (Group M). DPOAEs measurements
between 0.9961 and 8.0003 Hz as DP-gram and
input/output (I/O) functions were performed in the same
(left) ear of all rats on days 0, 1st, 5th and 12th. Prior to
death, the last DPOAEs measurements and blood samples
were taken. In the C group, statistically significant DPOAE
amplitude reductions were detected at 2.5195, 3.1758,
3.9961, 5.0391, 6.3516 and 8.0039 Hz frequencies
(p\0.05) between 0th and 1st, 0th and 5th and 0th and
12th days’ measurements (p\0.05). Serum level of MDA,
TAC and OSI levels were significantly higher in the C
group versus K group (p\0.05). In the CM group, there
were no significant differences at all frequencies between
0th and other days’ measurements (p[0.05) and the
serum levels of all biochemical parameters were shifted
toward normal values, similar to the K group (p\0.05).
No significant differences were detected in the either M or
K group’s measurements. According to these results, cisplatin-related
ototoxicity has been significantly prevented
by MOL.
