Özet:
Follicular dendritic cell sarcoma (FDCS) of the head and
neck region, associated with Castleman's disease (CD), is
an extremely rare entity. To the best of our knowledge, we
report the first case demonstrating the transformation of
the former into the latter as documented in the same
lymph node disection material.
A 45-year-old female presented to our hospital with right
sided neck swelling. Radiologic imaging showed a well
defined 3.5x3.5cm mass of soft tissue at the right side of
the neck with multiple bilateral cervical lymph nodes.
Excision of the right neck mass with lymph node disection
was performed. Microscopic examination and
immunohistochemical findings showed features of
follicular dendritic cell sarcoma. The associated lymph
nodes exhibited changes consistent with hyaline-vascular
type CD , follicular dendritic cell hyperplasia and foci of
overgrowth in which FDCS possibly evolved.
This report confirms the evolving of FDCS in the setting of
follicular dendritic cell hyperplasia occurring in
Castleman's disease.
