Klinik ve epidemiyolojik bulgular kanser etyolojisinde
serbest radikallerin üstlendi¤i muhtemel rolü
destekleyici kan›tlar sunmaktad›r. Serbest radikal yokediciler
ve inhibitörlerinin kanser sürecini erteledi¤i ya da
engelledi¤i gösterilmifltir.
Hastalar ve Yöntemler: Bafl-boyun kanserli 35 hastan›n
serumlar›nda adenozin deaminaz, ksantin oksidaz,
süperoksit dismutaz ve glutatyon peroksidaz aktiviteleri
ve malondialdehit düzeyi ölçülerek sa¤l›kl› kontrol
grubu ile karfl›laflt›r›ld›.
Bulgular: Serum adenozin deaminaz aktivitesi, kanserli
hastalarda kontrol grubu ile karfl›laflt›r›ld›¤›nda azalm›fl
bulundu (p<0.001). Glutatyon peroksidaz ve ksantin oksidaz
aktiviteleri ile malondialdehit düzeyi kontrol grubuna
oranla hafif artm›fl bulunmakla birlikte arada anlaml› farkl›l›k
yoktu. Serum süperoksit dismutaz aktivitesi ise kontrol
grubuna oranla hafif azalm›fl bulundu.
Sonuç: Bu sonuçlar, serum adenozin deaminaz aktivitesinin
bafl-boyun kanserlerinin tan› ve takibinde yararl›
olabilece¤ini göstermektedir. Bafl-boyun kanserli hastalarda
adenozin deaminaz düzeyindeki art›fl›n nedenleri
üzerinde genifl tabanl› çal›flmalara ihtiyaç vard›r.
Clinical and epidemiological findings have
provided evidence supporting a role of free radicals in
the etiology of cancer. Scavengers and inhibitors of
free radical processes have been demonstrated to prevent
or delay the neoplastic process.
Patients and Methods: Adenosine deaminase, xanthine
oxidase, superoxide dismutase, and glutathione peroxidase
activities and malondialdehyde levels were measured
in the sera of 35 patients with head and neck cancers
and compared to those of healthy control subjects.
Results: Serum adenosine deaminase activity was
found to be significantly increased in the patient group
(p<0.001). Compared to the control group, glutathione
peroxidase and xanthine oxidase activities and malondialdehyde
levels were slightly higher and serum superoxide
dismutase activity was slightly lower in the patient
group, with none reaching statistical significance.
Conclusion: The results indicate that serum adenosine
deaminase activity may be helpful in the diagnosis and
follow-up of head and neck cancers. Further studies with
a larger cohort of patients are needed to clarify the exact
mechanism of adenosine deaminase elevation.
