Adenosine deaminase xanthine oxidase superoxide dismutase glutathioneperoxidase activities and malondialdehyde levels in the sera of patients withhead and neck carcinoma

Abstract

Klinik ve epidemiyolojik bulgular kanser etyolojisinde serbest radikallerin üstlendi¤i muhtemel rolü destekleyici kan›tlar sunmaktad›r. Serbest radikal yokediciler ve inhibitörlerinin kanser sürecini erteledi¤i ya da engelledi¤i gösterilmifltir. Hastalar ve Yöntemler: Bafl-boyun kanserli 35 hastan›n serumlar›nda adenozin deaminaz, ksantin oksidaz, süperoksit dismutaz ve glutatyon peroksidaz aktiviteleri ve malondialdehit düzeyi ölçülerek sa¤l›kl› kontrol grubu ile karfl›laflt›r›ld›. Bulgular: Serum adenozin deaminaz aktivitesi, kanserli hastalarda kontrol grubu ile karfl›laflt›r›ld›¤›nda azalm›fl bulundu (p<0.001). Glutatyon peroksidaz ve ksantin oksidaz aktiviteleri ile malondialdehit düzeyi kontrol grubuna oranla hafif artm›fl bulunmakla birlikte arada anlaml› farkl›l›k yoktu. Serum süperoksit dismutaz aktivitesi ise kontrol grubuna oranla hafif azalm›fl bulundu. Sonuç: Bu sonuçlar, serum adenozin deaminaz aktivitesinin bafl-boyun kanserlerinin tan› ve takibinde yararl› olabilece¤ini göstermektedir. Bafl-boyun kanserli hastalarda adenozin deaminaz düzeyindeki art›fl›n nedenleri üzerinde genifl tabanl› çal›flmalara ihtiyaç vard›r.

Clinical and epidemiological findings have provided evidence supporting a role of free radicals in the etiology of cancer. Scavengers and inhibitors of free radical processes have been demonstrated to prevent or delay the neoplastic process. Patients and Methods: Adenosine deaminase, xanthine oxidase, superoxide dismutase, and glutathione peroxidase activities and malondialdehyde levels were measured in the sera of 35 patients with head and neck cancers and compared to those of healthy control subjects. Results: Serum adenosine deaminase activity was found to be significantly increased in the patient group (p<0.001). Compared to the control group, glutathione peroxidase and xanthine oxidase activities and malondialdehyde levels were slightly higher and serum superoxide dismutase activity was slightly lower in the patient group, with none reaching statistical significance. Conclusion: The results indicate that serum adenosine deaminase activity may be helpful in the diagnosis and follow-up of head and neck cancers. Further studies with a larger cohort of patients are needed to clarify the exact mechanism of adenosine deaminase elevation.