Abstract:
Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as
protection against oxidative stress, signal transduction and protein folding. Some proteins involved in
redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess
the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of
yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several
pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and
degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.
