Abstract:
Merosin-negative congenital muscular dystrophy is a rare
genetic disease of childhood involving the central and peripheral
nervous system. There were high signal intensities
throughout the centrum semiovale, periventricular, and subcortical
white matters on T2-weighted images in a 4-year-old
girl with merosin-negative congenital muscular dystrophy. An
apparent diffusion coefficient map revealed increased signal
intensity and apparent diffusion coefficient values in the
periventricular and deep white matters. It may be attributable
to increased water content in the white matter because of an
abnormal blood-brain barrier rather than to decreased or
abnormal myelination.
