Özet:
We screened 29 children with autism for mutation in the human
secretin gene using single-strand conformation polymorphism. No
mutation was detected in exon 2, 3, or 4. Polymerase chain reaction
and DNA sequence of 5´ variable number of tandem repeats
showed two polymorphisms with deletion or duplication of a
repeat unit that failed to show any gene expression with transient
transfection assay. We did not find evidence of a relationship
between human secretin gene mutation and autism.
