Abstract:
Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on
bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats.
Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3
(TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4
(LB), rats received only Lycium barbarum.
Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased
ileal E. coli counts and intestinal damage but it did not alter BT frequency.
Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this
model.
