Abstract:
Abstract We investigated the effect of caffeic acid
phenethyl ester in rat ileum injury induced by chronic biliary
obstruction. Swiss albino rats were divided into three groups:
Group 1, sham (n = 7); Group 2, common bile duct ligation
(n = 7); and Group 3, common bile duct ligation plus caffeic
acid phenethyl ester (n = 7). In the caffeic acid phenethyl
ester-treated rats, ileum tissue levels of malondialdehyde
and myeloperoxidase were significantly lower than those
of the bile duct-ligated rats (P < 0.001). The levels of tumor
necrosis factor-α, interleukin-6, and interleukin-1α in the
caffeic acid phenethyl ester group were significantly lower
than those in the bile duct ligation group (P < 0.03, P < 0.01,
and P < 0.02 respectively). The present study demonstratesthat intraperitoneal administration of caffeic acid phenethyl
ester in bile duct-ligated rats reduces intestinal oxidative
stress. This effect may be useful in the preservation of intestinal
damage in cholestasis.
