Behcet's disease as a causative factor of cerebral venous sinus
Title:
Behcet's disease as a causative factor of cerebral venous sinus;
thrombosis: subgroup analysis of data from the VENOST study
Uluduz, D; Midi, I; Duman, T; Colakoglu, S; Tufekci, A; Bakar, M; Nazliel, B; Tascilar, N; Goksan, B; Sungur, MA; Kozak, HH; Demir, S; Misirli, CH; Kucukoglu, H; Cinar, N; Domac, FM; Ozturk, S; Yayla, V; Karahan, AY; Afsar, N; Goksu, EO; Mengulluoglu, N; Aytac, E; Yesilot, N; Ince, B; Yalin, OO; Oruc, S; Demirci, S; Senol, MG; Yilmaz, A; Gokce, M; Kusbeci, OY; Uzuner, G; Caglayan, HZB; Acikgoz, M; Zeydan, B; Ozdag, F; Baybas, S; Ekmekci, H; Cabalar, M; Yaman, M; Yurekli, VA; Tekeli, H; Genc, H; Utku, U; Tokuc, FEU; Uzuner, N; Bektas, H; Kablan, Y; Goksel, BK; Milanlioglu, A; Orken, DN; Aluclu, U
Date:
2019
Abstract:
Objective This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behcet's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST).
Methods VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis.
Results BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 18-36 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%).
Conclusions BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score 2).
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