In this multicenter retrospective analysis, we aimed to present clinical, laboratory and treatment results of 94 patients with Hairy cell leukemia diagnosed in 13 centers between 1990 and 2014. Sixty-six of the patients were males and 28 were females, with a median age of 55. Splenomegaly was present in 93.5% of cases at diagnosis. The laboratory findings that came into prominence were pancytopenia with grade 3 bone marrow fibrosis. Most of the patients with an indication for treatment were treated with cladribine as first-line treatment. Total and complete response of cladribine was 97.3% and 80.7%. The relapse rate after cladribine was 16.6%, and treatment related mortality was 2.5%. Most preferred therapy ( 95%) was again cladribine at second-line, and third line with CR rate of 68.4% and 66.6%, respectively. The 28-month median OS was 91.7% in all patients and 25-month median OS 96% for patients who were given cladribine as first-line therapy. In conclusion, the first multicenter retrospective Turkish study where patients with HCL were followed up for a long period has revealed demographic characteristics of patients with HCL, and confirmed that cladribine treatment might be safe and effective in a relatively large series of the Turkish study population. Copyright (C) 2014 John Wiley & Sons, Ltd.
C1 [Hacioglu, Sibel; Dogu, Mehmet Hilmi; Keskin, Ali] Pamukkale Univ, Dept Hematol, TR-20070 Denizli, Turkey.
[Bilen, Yusuf; Yildirim, Rahsan] Ataturk Univ, Dept Hematol, Erzurum, Turkey.
[Eser, Ali] Marmara Univ, Dept Hematol, Istanbul, Turkey.
[Sivgin, Serdar] Erciyes Univ, Dept Hematol, Kayseri, Turkey.
[Gurkan, Emel] Cukurova Univ, Dept Hematol, Adana, Turkey.
[Aydogdu, Ismet] Celal Bayar Univ, Dept Hematol, Manisa, Turkey.
[Yilmaz, Mehmet] Gaziantep Univ, Dept Hematol, Gaziantep, Turkey.
[Kayikci, Omur] Ankara Oncol Educ & Res Hosp, Dept Hematol, Ankara, Turkey.
[Tombak, Anil] Mersin Univ, Dept Hematol, Mersin, Turkey.
[Kuku, Irfan] Inonu Univ, Dept Hematol, Malatya, Turkey.
[Celebi, Harika] Diskapi Yildirim Beyazit Educ & Res Hosp, Dept Hematol, Ankara, Turkey.
[Akay, Meltem Olga] Osmangazi Univ, Dept Hematol, Eskisehir, Turkey.
[Esen, Ramazan] Yuzuncu Yil Univ, Dept Hematol, Van, Turkey.
[Korkmaz, Serdal] Cumhuriyet Univ, Dept Hematol, Sivas, Turkey.