Özet:
Fluconazole, an azole antifungal agent, inhibits the fungal cytochrome
P450 enzyme. Although in vitro data show that fluconazole is not a potent
inhibitor of mammalian P450 enzymes, hyperkalemia secondary to
adrenal insufficiency associated with fluconazole has been described
rarely [1–3]. However, life-threatening severe hyperkalemia related to administration
of intravenous fluconazole without adrenal suppression has
not been reported before.