Özet:
Progressive liver failure is rarely seen in tuberculosis
chemoprophylaxis with isoniazid. We present a case of a
32-year-old woman admitted to our clinic reporting
abdominal pain, nausea and vomiting for 2 days. The
initial diagnosis was fulminant toxic hepatitis due to
isoniazid chemoprophylaxis, which was treated
successfully with living donor transplantation.
Tuberculosis continues to be a significant public health
problem. Isoniazid-related hepatotoxicity is extremely rare
in adults. The only treatment in cases of fulminant liver
failure is orthotopic liver transplantation from a deceased
or living donor. If a deceased donor is not available or
the patient refuses this treatment, living donor
transplantation is the only choice. Although rare,
isoniazid used as protective therapy for pulmonary
tuberculosis can lead to fulminant liver failure. When
cadaveric liver transplantation is not available, living
donor liver transplantation is vital.