Özet:
The research toward understanding the role of oligomeric amyloids in Alzheimer’s disease (AD) hasgained considerable attention in recent years. The information obtained in this direction showed thatAmyloid Derived Diffusible Ligands (ADDLs) cause ambiguous ions movements across lipid bilayers inthe plasma membrane and consequently alter its dielectric properties such as permeability. Nevertheless,how this amyloid protein selectively alters the permeability of the cell membrane has not been noted downbecause none of the specific receptors have been identified for ADDLs binding. As a result of the increaseof cellular calcium level, local micromechanical properties of cells can change and thus inducereorganization of cytoskeletal structures that can cause neurodegenerative disorders such as AD.Therefore, in this study we have tried to specify the effect of alteration of permittivity and permeability ofsynaptic channel as modeling synaptic cleft by an RC circuit. By linking the electronic neuronal modelsthat we have previously designed with the RC cleft model, when the information transferred from oneneuron to another, the rate of error measured on the later neuron circuit with reference to the former onewas determined with respect to the rate of change of R and C values individually. It was observed that Cand R, and hence permeability of the synaptic channel do affect the communication error. It is concludedthat a healthy synaptic channel conserves optimum resistivity and capacity levels at which the inter neuronal signaling is achieved at a minimum error. These results could be linked to hypothesize thatamyloids have a common feature in structuring channel-like concentrations which are supported by theirelectrical activity as well as the rate of permeability of Calcium like cautions.
