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Toplam kayıt 57, listelenen: 1-20

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Sensitization of cervical cancer cells to cisplatin by genistein the role of NF B and akt mTOR signaling pathways

Şahin, Kazım; Tuzcu, Mehmet; Başak, Neşe; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Şahin, Fikrettin; Küçük, Ömer (Journal of Oncology Volume, 2012)

Cervical cancer is among the top causes of death from cancer in women. Cisplatin-based chemotherapy has been shown to improve survival; however, cisplatin treatment is associated with toxicity to healthy cells. Genistein ...
Radical scavenging activity and vitexin content of Vitex agnus castus leaves and fruits

Gökbulut, Alper; Özhan, Onural; Karacaoğlu, Melek; Şarer, Engin (FABAD Journal of Pharmaceutical Sciences, 2012)

The goal of this study was to determine some of the important phenolic constituents of the methanolic extracts of the leaves and fruits of Vitex agnus-castus by RP-HPLC with regard to the results obtained from radical ...
Relationship between depression and loneliness in elderly and examination of influential factors

Aylaz, Rukiye; Aktürk, Ümmühan; Erci, Behice; Öztürk, Hatice; Aslan, Hakime (Archives of Gerontology and Geriatrics, 2012)

This study was planned and conducted for the purpose of examining the relationship between depression and loneliness in elderly people and the influencing factors. The study was a descriptive and correlational study and ...
Oral administration of hesperidin a citrus flavonone in rats counteracts the oxidative stress the inflammatory cytokine production and the hepatotoxicity induced by the ingestion of 2 3 7 8 tetrachlorodibenzo p dioxin TCDD

Bentli, Recep; Çiftçi, Osman; Çetin, Aslı; Ünlü, Merve; Başak, Neşe; Çay, Mahmut (Eur.Cytokine Netw, 2013)

The objective of the current study was to investigate the protective effects of hesperidin against oxidative stress, altered cytokines levels and histological changes in rats induced by 2,3,7,8-tetrachlorodibenzo-p-diox ...
In vitro antioxidant activity total phenolic content and phenolic composition of Inula heterolepis

Karacaoğlu, Melek; Gökbulut, Alper; Özhan, Onural; Şarer, Engin (Planta Medica, 2013)

Inula heterolepis Boiss., a perennial herbaceous plant (15 – 40 cm) widespread throughout the Eastern Mediterranean region, is used topically in folk medicine against loss of appetite, headaches and hemorrhoids. To the ...
Antioxidant and antimicrobial activities and phenolic compounds of selected Inula species from Turkey

Gökbulut, Alper; Özhan, Onural; Satılmış, Basri; Batçıoğlu, Kadir; Günal, Selami; Şarer, Engin (Natural Product Communications, 2013)

Three Inula species, I. viscosa, I. helenium ssp. turcoracemosa and I. montbretiana, collected from different locations of Anatolia were investigated for their antioxidant and antimicrobial potential, and their total ...
The protective effects of apocynin on kidney damage caused by renal ischemia reperfusion

Altıntaş, Ramazan; Polat, Alaadin; Vardı, Nigar; Beytur, Ali; Yıldız, Azibe; Sağır, Mustafa; Parlakpınar, Hakan; Oğuz, Fatih (Journal of Endourology, 2013)

Purpose: This experimental study was designed to explore the protective effect of apocynin, the NADPH-oxidase inhibitor, on kidney damage induced by ischemia/reperfusion (I/R) in a rat model. Methods: Thirty-two rats ...
Phenolic compounds and antimicrobial activity of inula sarana boiss

Özhan, Onural; Gökbulut, Alper; Günal, Selami; Şarer, Engin (Planta Medica, 2013)

The genus Inula (Asteraceae) has more than hundred species distributed mainly in Europe, Africa and Asia. Inula species are used as a folk medicine due to their anti-inflammatory, antiseptic, antipyretic, hepatoprotective, ...
Protective effects of melatonin and d glucan againstliver injury in rats a comparative study

Aydoğan, Mustafa Said; Erdoğan, Mehmet Ali; Polat, Alaadin; Yücel, Aytaç; Özgül, Ülkü; Parlakpınar, Hakan; Duran, Zeynep Rümeysa; Yıldız, Azibe; Durmuş, Mahmut (Advances in Clinical and Experimental Medicine, 2013)

Objectives. The aim of this study was to investigate the possible protective effects of melatonin and β-d-glucan against ischemia-reperfusion (IR) injury in rats. Materials and Methods. Forty rats were randomly divided ...
Investigation of ICAM 1 and 3 integrin gene variations in patients with brain tumors

Yılmaz, Ümit; Zeybek, Şakir Ümit; Timirci Kahraman,Özlem; Kafadar, Ali Metin; Toptaş, Bahar; Yılmaz, Nesibe; Çelik, Faruk; Yaylım, İlhan (Asian Pacific Journal of Cancer Prevention, 2013)

Background: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. β3 integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor ...
Mechanical properties and cytotoxicity of hydroxyapatite based bone grafts applied mechanics and materials

Demirel, Mehtap; Aksakal, Bünyamin; Başak, Neşe (Applied Mechanics and Materials, 2013)

Hydroxyapatite (HA) based bone grafts were synthesized by sol-gel method at various pH values 5, 7, 9 and 12, respectively. In order to ascertain the influence of the obtained bone grafts on the morphology, sinterability ...
Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin induced diabetes and evaluation of SMA expression

Elbe, Hülya; Vardı, Nigar; Orman, Doğan; Taşlıdere, Elif; Yıldız, Azibe (Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 2014)

Objective: Diabetes mellitus is one of the chronic metabolic diseases which is characterized by microvascular and macrovascular complications. This study was designed to investigate the improving the effects of amnioguanidine ...
The beneficial effects of 18 glycyrrhetinic acid following oxidative and neuronal damage in brain tissue caused by global cerebral ischemia reperfusion in a C57BL J6 mouse model

Öztanır, Mustafa Namık; Çiftçi, Osman; Çetin, Aslı; Durak, Mehmet Akif; Başak, Neşe; Akyuva, Yener (Neurol Sci, 2014)

This study investigated the effects of 18bglycyrrhetinic acid (GA) on neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion (I/R) in C57BL/J6 mice. All subjects (n = 40) were equally divided into ...
A novel schiff base derivative for effective treatment of azoxymethane induced colon cancer

Doğan, Ayşegül; Başak, Neşe; Demirci, Selami; Telci, Dilek; Dede, Bülent; Tuzcu, Mehmet; Özercan, İbrahim Halil; Şahin, Kazım; Şahin, Fikrettin (IJPSR, 2014)

The field of cancer research has been emerged in recent years for the development of specific drugs to cancer treatment. New agents with the ability to provide efficient treatment by reducing side effects has led to new ...
Polymorphisms in MMP 2 and TIMP 2 in Turkish patients with prostate cancer

Yaykaşlı, Kürşat Oğuz; Kayıkçı, Muhammet Ali; Yılmaz, Nesibe; Soğuktaş, Hatice; Düzenli, Selma; Arslan, Ali Osman; Metin, Ahmet; Kaya, Ertuğrul; Hatipoğlu, Ömer Faruk (TURKISH JOURNAL OF MEDICAL SCIENCES, 2014)

Aim: Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer deaths in the Western male population. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) ...
The effect of melatonin on acetylsalicylic acid induced kidney and testis damage

Altıntaş, Ramazan; Polat, Alaadin; Parlakpınar, Hakan; Vardı, Nigar; Beytur, Ali; Oğuz, Fatih; Sağır, Mustafa; Yıldız, Azibe; Duran, Zeynep Rümeysa (Human & Experimental Toxicology, 2014)

The aim of this study was to evaluate the acute effect of high-dose acetylsalicylic acid (ASA) on kidney and testis, and the potential protective and therapeutic effects of melatonin on ASA-related pathology. A total of ...
Association between survivin gene polymorphisms and the susceptibility to colon cancer development in the turkish population

Yılmaz, Nesibe; Yaykaşlı, Kürşat Oğuz; Yılmaz, Ümit; Eröz, Recep; Uzunlar, Ali Kemal; Ankaralı, Handan; Şahiner, Cem; Baltacı, Davut (Asian Pacific Journal of Cancer Prevention, 2014)

Background: Colon cancer is one of the most common cancers worldwide. Apoptosis is a necessary physiological process for cell elimination which is very important both cellular homeostasis and cell proliferation and ...
Hesperidin protects testicular and spermatological damages induced by cisplatin in rats

Kaya, Kürşat; Çiftçi, Osman; Çetin, Aslı; Doğan, Halef; Başak, Neşe (Andrologia, 2015)

The clinic usage of cisplatin, an anticancer drug, is limited due to it has many side effects in many systems and organs. In this context, it was aimed to investigate the protective effect of hesperidin, a citrus flavonoid, ...
Protective effects of apocynin on cisplatin induced hepatotoxicity in rats

Çağın, Yasir Furkan; Erdoğan, Mehmet Ali; Şahin, Nurhan; Parlakpınar, Hakan; Atayan, Yahya; Polat, Alaadin; Vardı, Nigar; Yıldız, Azibe; Tanbek, Kevser (Archives of medical research, 2015)

Background and Aims. Despite it being a highly potent antineoplastic drug, cisplatin has important toxic adverse effects limiting its use such as nephrotoxicity, neurotoxicity and ototoxicity. It is thought that ...
The protective effect of apocynin on testicular ischemia reperfusion injury

Özbek, Özkan; Altıntaş, Ramazan; Polat, Alaadin; Vardı, Nigar; Parlakpınar, Hakan; Sağır, Mustafa; Duran, Zeynep Rümeysa; Yıldız, Azibe (The journal of ürology, 2015)

We investigated the protective effect of the NADPH oxidase inhibitor apocynin on testicular damage induced by ischemia-reperfusion injury in rats. Materials and Methods A total of 32 rats were randomly divided into ...

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