Abstract:
We aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We
measured total antioxidant capacity (TAC), paraoxonase (PON), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant
levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a
significant difference between the TAC, PON, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the
control group. The two-way comparison to clarify the group creating the difference showed that the TAC, PON, and ARE antioxidants
were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There
was no significant difference between the PD without A and control groups for TAC, PON, ARE and MDA levels. We clearly demonstrated
that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings
suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.
