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Öğe Association between latent toxoplasmosis and clinical course of schizophrenia-continuous course of the disease is characteristic for Toxoplasma gondii-infected patients(Czech Academy of Sciences, 2015) Çelik T.; Kartalci S.; Aytaş O.; Akarsu G.A.; Gözükara H.; Ünal S.The aim of the present study was to investigate the association between various clinical aspects of schizophrenia and seropositivity against Toxoplasma gondii (Nicolle et Manceaux, 1908). We selected 94 patients with schizophrenia and investigated the seropositivity rate for anti-T. gondii IgG antibodies by ELISA. Clinical parameters of schizophrenic patients such as illness type and status, clinical course, awareness of the illness and need for electroconvulsive therapy (ECT) were compared with their serological status. Anti-T. gondii IgG antibodies were detected in 43 (46%) of schizophrenic patients. Chronic patients had a rate of 34 (72%) seropositivity, whereas 9 (22%) of the patients with partial remission showed evidence of latent toxoplasmosis. Of continuous patients, 35 (81%) were found to be seropositive and this rate was significantly more than in the other groups. The rate of latent toxoplasmosis was detected significantly higher in patients who lack awareness of schizophrenia (36, i.e. 72%) than the patients who were aware of their illnesses (7, i.e. 16%). Anti-T. gondii IgG antibodies were detected in 38 (70%) of ECT performed patients while this percentage was 13% in the ones who had never been treated with ECT. This difference was also statistically significant. We showed that Toxoplasma-infected subjects had 15× higher probability of having continuous course of disease than Toxoplasma-free subjects. Our results put forth the possibility of latent toxoplasmosis to have a negative impact on the course of schizophrenia and treatment response of schizophrenic patients. © Institute of Parasitology, Biology Centre CAS.Öğe A Retrospective Evaluation of Serological Results of Cystic Echinococcosis Suspected Cases Admitted to Adıyaman Training and Research Hospital Between 2013-2020(Galenos Publishing House, 2022) Çelik T.; Alev C.; Akgün S.; Güldoğan E.; Şahin F.Objective: Cystic echinococcosis (CE) is prevalent, especially in animals in Turkey and stands as a significant zoonose. In this study, we aimed to retrospectively evaluate the indirect hemagglutination (IHA) tests results performed on samples of CE suspected patients in microbiology laboratory of our hospital. Methods: One thousand six hundred-seven files of patients admitted to hospital between January 2013 and December 2020 were examined for the presence of anti-E. granulosus immunoglobulin G antibodies. The patient’s socio-demographic characteristics and radiological data were obtained from the hospital automatization system. Results: A total of 1.607 file records; 644 (40.1%) males and 963 (59.9%) females, aged between 1-96 years (average 45.26±19.91) were examined. It was found that 244 (15.18%) of the patients were positive, 78 (4.86%) were determined at an intermediary value and 1.285 (79.96%) were negative. According to the IHA method a titer of 1/320 and above were evaluated as positive. Compared to anti-E. granulosus IgG antibody titers 164 radiological data; while 28.6% of 21 patients who are evaluated as negative (1/80) and 46.2% of 78 patients who were evaluated as intermediary titer (1/160) had cystic lesion in the radiological findings. Conclusion: Based on the data, it is suggested that while interpreting the patient’s serum antibody titers, patient’s clinical and radiological findings should also be taken into account. If possible, it should be used along with another serological method like ELISA to assist CE patient’s diagnosis and treatment. © 2022 Turkish Society for Parasitology.Öğe Subcutaneous fat necrosis mimicking a malignant mass associated with the left internal oblique and the sartorius muscles in a 3 months old boy: Differential diagnosis(Turkiye Klinikleri, 2009) Si?irci A.; Karaman A.; Başsüllü N.; Çelik T.Subcutaneous fat necrosis (SCFN) is a rare, self-limited and benign disorder that develops after birth. A 3-month-old-boy presented with a semi-mobile mass under the skin without erythema on the left inguinal area. Ultrasound (US) revealed a mass within the subcutaneous fat layer over the left internal oblique and the sartorius muscles with heterogenous echogenicity. Computed tomography (CT) showed that the mass had a smooth border with partially spicular extensions to the subcutaneous fat. The presumptive diagnosis was rhabdomyosarcoma. Surgical exploration and excision biopsy were performed. The pathological examination revealed SCFN. Copyright © 2009 by Türkiye Klinikleri.Öğe Transient renal medullary hyperechogenicity in newborns with acute renal failure and dehydration: Ultrasonography follow-up(2006) Çelik T.; Firat A.K.; Kahraman A.S.; Erdem G.; Karakaş H.M.; Yakinci C.Our purpose was to assess the time interval between the visualization of renal medullary hyperechogenicity and its resolution in neonates with acute renal failure. Seven newborns with renal medullary hyperechogenicity and acute renal insufficiency noted on ultrasonography (US) were included in the study group. Their ages were ranged between three and six days. All of the patients underwent US at the first presentation and in the follow-up. In all of the patients diffuse medullary hyperechogenicity was noted in the bilateral kidney. Biochemistry examinations revealed abnormal BUN and creatine level in all neonates and additional hypernatremia in four of them. The medullary hyperechogenicity totally disappeared between the 10th and 30 th days of the neonatal period. Renal functions had normalized before the resolution of medullary hyperechogenicity between the 7th and 10th days. Transient medullary hyperechogenicity may be delayed due to presence of abnormal renal functions. For this reason, while deciding to examine these patients for metabolic disease. persistent renal medullary hyperechogenicity after 10 days in the neonatal period should be evaluated in accordance with biochemistry findings.
