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    Increased frequency of restless legs syndrome in atopic dermatitis
    (Clinical and Experimental Dermatology, 2012) Çiçek, Demet; Halisdemir, Nurhan; Dertioğlu, S. B.; Berilgen, M. S.; Özel, S.; Çolak, C.
    Background. Restless legs syndrome (RLS) is characterized by an unpleasant sensation in the legs, which is difficult to describe, but produces an urge to move the legs frequently. Aim. To assess the prevalence and severity of RLS in patients with atopic dermatitis (AD) and patients with psoriasis, and to investigate the factors potentially associated with RLS. Methods. In total, 253 people were enrolled (120 with AD, 50 with psoriasis and 83 healthy controls). A diagnosis of RLS was made according to the criteria of the International RLS Study Group (IRLSSG), and severity was assessed using the IRLSSG severity scale. Results. RLS was significantly more common in patients with AD (40.8%) than in patients with psoriasis (18.0%) or in controls (10.8%) (P < 0.01 and P < 0.001, respectively). Prevalence of RLS was higher in patients with active AD than in those with inactive AD (55.3% vs. 23.6%) or controls. There was a significant difference in RLS prevalence between patients with active and those with iactive AD, between patients with active AD and healthy controls, between patients with active AD and patients with psoriasis, and between patients with inactive AD and healthy controls (P < 0.001, P < 0.001, P < 0.001, P = 0.04, respectively). There was no significant difference in RLS prevalence between patients with active AD and patients with psoriasis, or between patients with psoriasis and healthy controls (P > 0.05). Of patients who were positive for RLS, 56.9% had a family history of atopy and 40.3% had a family history of RLS, and there was a significant relationship between the presence of RLS and family history of atopy or RLS (P < 0.001 for both). Conclusions. RLS is common in patients with AD, particularly in those with active disease.
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    Increased frequency of restless legs syndrome in atopic dermatitis
    (Clinical and Experimental Dermatology, 2012) Çiçek, Demet; Halisdemir, Nurhan; Çolak, Cemil
    Background. Restless legs syndrome (RLS) is characterized by an unpleasantsensation in the legs, which is difficult to describe, but produces an urge to move thelegs frequently.Aim. To assess the prevalence and severity of RLS in patients with atopic dermatitis(AD) and patients with psoriasis, and to investigate the factors potentially associatedwith RLS.Methods. In total, 253 people were enrolled (120 with AD, 50 with psoriasis and 83healthy controls). A diagnosis of RLS was made according to the criteria of theInternational RLS Study Group (IRLSSG), and severity was assessed using the IRLSSGseverity scale.Results. RLS was significantly more common in patients with AD (40.8%) than inpatients with psoriasis (18.0%) or in controls (10.8%) (P < 0.01 and P < 0.001,respectively). Prevalence of RLS was higher in patients with active AD than in thosewith inactive AD (55.3% vs. 23.6%) or controls. There was a significant difference inRLS prevalence between patients with active and those with iactive AD, betweenpatients with active AD and healthy controls, between patients with active AD andpatients with psoriasis, and between patients with inactive AD and healthy controls(P < 0.001, P < 0.001, P < 0.001, P = 0.04, respectively). There was no significantdifference in RLS prevalence between patients with active AD and patients withpsoriasis, or between patients with psoriasis and healthy controls (P > 0.05). Ofpatients who were positive for RLS, 56.9% had a family history of atopy and 40.3%had a family history of RLS, and there was a significant relationship between thepresence of RLS and family history of atopy or RLS (P < 0.001 for both).Conclusions. RLS is common in patients with AD, particularly in those with activedisease.
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    Investigation of attention deficit and hyperactivity disorder in adult patients with atopic dermatitis
    (International Journal of Psychiatry in Clinical Practice, 2009) Çiçek, Demet; Kandi, Başak; Bakar Dertlioğlu, Selma; Günay, Sennur; Halisdemir, Nurhan; Turgay, Atilla; Çolak, Cemil
    Background. Atopic dermatitis (AD) is a common chronic inflammatory disease that is associated with significant psychosocial morbidity and a decrease in health-related quality of life. Attention deficit hyperactivity disorder may be present in atopic dermatitis patients. Objective. The present study aims to investigate the co-presence of ADHD in adult patients with AD. Material and method. The study registered 60 adult patients with AD (48 females and 12 males) and 50 non-atopic control subjects (38 females and 12 males). The AD patient group and the control group were assessed using the Turgay adult Attention-Deficit/Hyperactivity Disorder (ADD/ADHD) DSM-IV-Based Diagnostic Screening and Rating Scale (Turkish Version), which was studied by a team of psychologists and psychiatrists in Turkey for validity, reliability and norms. The scale covers three dimensions of the disease, namely inattention, hyperactivity and impulsivity, and associated features of ADHD. The groups were compared and contrasted in terms of their similarities and differences in ADD/ADHD symptoms. Results. Three sub-dimensions of ADD/ADHD scale (Attention Deficit, Hyperactivity/ Impulsivity and Problem subdivisions) in AD patients were found statistically significantly elevated relative to controls (PB0.001, PB0.001, PB 0.001, respectively). Conclusions. In conclusion we established the co-presence of ADHD in AD patients in the adult age group.