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Öğe Boyun Orta Hattında Tiroglossal Duktus Kisti Sanılan Ektopik Tiroid Doku Adenomu(İnönü Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Malatya, Türkiye, 2013) Toplu, Yüksel; Karataş, Erkan; Çetinkaya; Çiçek, Mehmet Turan; Çetinkaya, ZekeriyaÖz: Tiroglossal duktus kisti genellikle embriyolojik tiroid göçü sırasında embriyojenik kanalın tıkanmasındaki bir problemden kaynaklanır. Bu doğumsal lezyon pediatrik yaş grubunda en sık görülen boyun orta hat kitleleridir. Bunlar genellikle çiğneme, yutma dil hareketleri ve dilin dışarı çıkarılması ile hareket eden problemsiz kitlelerdir. Bu hastalarda enfeksiyon, süpürasyon ve büyüme gibi komplikasyonlar görülebeilir. Yutma güçlüğü ve trakea basısı nadiren görülebilir. Bazen bu lezyonlar sadece tiroid dokusu içerebilir. Bu yüzden cerrahi öncesi yapılacak doğru görüntüleme çalışmaları büyük önem arz eder. Ektopik tiroid dokusu adenomları nadirdir fakat tiroglossal duktus ile ilişkili olan ektopik tiroid dokusu adenomları çok daha nadirdir. Bu makalede, ektopik tiroid dokusu adenomu olan bir olgu sunuldu.Öğe A comparative analysis of long-term life qualities of head and neck cancer (nasopharyngeal, hypopharyngeal and laryngeal cancers) patients who were treated with the intensity-modulated radiation therapy (IMRT): Expectations and outcomes(2021) Aslan, Mehmet; Çiçek, Mehmet TuranThe long-term quality of life outcomes of head-neck cancer patients who were treated with Intensity-modulated radiation therapy (IMRT) are not well known. The aim of this study was to determine the long-term quality of life and problems in patients undergoing IMRT in head-neck cancers. The study was conducted at a high-volume tertiary care setting. Patients who have received IMRT for head and neck cancers in our clinic, who completed at least one year following the completion of their therapy, and who are being followed up for the present, were included in the study. To assess patients’ quality of life and problems they experience, the updated(revised) version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Module (EORTC QLQ-H&N43) and The Arizona Sexual Experience Scale (ASEX) were administered to patients by the same clinician, using the face-to-face interview method. The study included 18,28,30 patients who received IMRT for hypopharyngeal, nasopharyngeal, and laryngeal cancer, respectively. Given the EORTC QLQ-H&N43 results of patient groups; contrary to expectations, mucosal dryness, sense and voice problems were observed as common problems in all patient groups. Thanks to protection of body integrity, good social contact and communication, a high level of satisfaction was observed in all patient groups. In conclusion; a high level of satisfaction was observed in patient groups treated with IMRT, despite long-term mucosal dryness, voice disturbances and sense problems, thanks to the preservation of body integrity and good social communication.Öğe A comparison of the platelet index, neutrophil-lymphocyteand platelet-lymphocyte ratios of patients withdifferentiated thyroid cancer and nodular hyperplasia(2021) Aslan, Mehmet; Çiçek, Mehmet TuranAim: In our study, it was aimed to determine the usability of the inexpensive, fast and easily accessible platelet index, NLR (Neutrophil to Lymphocyte ratio) and PLR (Platelet to Lymphocyte ratio) as predictive values in patients with differentiated thyroid cancer and nodular hyperplasia. Materials and Methods: The data of 454 patients operated due to differentiated thyroid cancers and nodular hyperplasia at our clinic between 2010 and 2020 and a control group consisting of 120 healthy individuals were retrospectively examined. The data of the patients and the control group were statistically analyzed. Results: The study included a total of 574 participants including 314 patients who received differentiated thyroid cancer surgery, 140 patients who received surgery due to thyroid nodular hyperplasia and a control group consisting of 120 healthy individuals. There was no significant difference among the groups in terms of age. There was a dominance of the female sex among the groups, but the difference was insignificant. There was no significant difference among the groups in terms of their MPV, PLR or NLR values. However, the PDW (Platelet Distribution Width) values were significantly higher among the differentiated thyroid cancer patients.Conclusion: In our study, we observed that the MPV, PLR and NLR values varied, but the differences were not statistically significant. The PDW values were significantly high. Considering the current literature, we concluded that, among the existing parameters, NLR is a more reliable constant value at the stage of diagnosis.Öğe The effect of intraoperative neuromonitoring on complications of hypocalcemia following(2021) Çiçek, Mehmet Turan; Aslan, MehmetHypocalcemia is a common and significant complication that may develop after a total thyroidectomy operation. In our study, the effects of neuromonitoring on the development of hypocalcemia in total thyroidectomy operations were retrospectively investigated. Patients who underwent only total thyroidectomy in our clinic between 2013 and 2020 and had no history of operation or radiation treatment in their neck region were retrospectively evaluated and divided into two groups. A total of 96 patients, 42 patients in Group 1 on whom neuromonitoring was used and 54 patients in Group 2 without neuromonitoring, were examined. Transient hypocalcemia was manifest in 12 (28.5%) of the 42 patients in Group 1 and 16 (29.6%) of the 54 patients in Group 2, while the difference between the two groups was not statistically significant (p=0.910). In total thyroidectomy operations, the proven benefits of using intraoperative neuromonitoring are still controversial. In our study, it was observed that intraoperative neuromonitoring did not make a significant difference in transient hypocalcemia development after total thyroidectomy operations.Öğe The effect of lycopene on the ototoxicity induced by cisplatin(Turkish Journal of Medical Sciences, 2014) Çiçek, Mehmet Turan; Kalcıoğlu, Mahmut Tayyar; Bayındır, Tuba; Toplu, Yüksel; Iraz, MustafaÖz: Başlık (İngilizce): Öz (İngilizce): Background/aim: To determine the efficacy of lycopene, which is considered an antioxidant agent, in decreasing the cochlear damage induced by cisplatin. Materials and methods: A total of 38 rats were randomized into 4 groups: control, cisplatin, cisplatin + lycopene, and lycopene-treated groups. In all groups, the distortion-product otoacoustic emission measurements were performed on days 0, 1, 2, and 5. Results: There were no significant differences between the control and lycopene groups at any frequencies. In the cisplatin group, the statistically significant differences were found in the measurements taken between day 0 and day 5 at all frequencies and between days 1 and 5 and days 2 and 5 at some frequencies (P < 0.05). In the cisplatin + lycopene group, a statistically significant difference was found at some frequencies between the measurements taken on days 0 and 5, days 1 and 5, and days 2 and 5 (P < 0.05). Contrary to the results found in the cisplatin group, hearing ability in the lycopene-treated group was observed as being preserved at low frequencies in the measurements taken on days 0 and 5 and days 2 and 5. Conclusion: The data of this study suggest that lycopene can prevent the development of ototoxicity induced by cisplatin, especially at low frequencies. Studies on this issue with longer durations and different dose ranges may contribute to the identification of potentially prophylactic effects of lycopene against cisplatin ototoxicity at higher frequencies, as well.Öğe MPV ve NLO Değerleri Kolesteatomu, Kronik Otitis Mediadan Ayırt Eder Mi?(2021) Aslan, Mehmet; Çiçek, Mehmet TuranAmaç: Kronik aktif otitis media (kolesteatomsuz) ve kolesteatom, kronik inflamatuar süreçle ilerleyen, sıklıkla hasara, fonksiyonel ve anatomik kayıplara neden olan yaygın kulak patolojileridir. Kronik aktif otitis media (kolesteatomsuz) ve kolesteatomun ayırıcı tanısı uygulanacak tedavinin belirlenmesinde ve oluşabilecek kayıplar açısından öngörü sağlar. Çalışmamızda kronik aktif otitis media ve kolesteatomlu hastaların ayırıcı tanısında trombosit indeksleri ile Nötrofil/Lenfosit oranları, Trombosit/Lenfosit oranlarının yardımcı bileşen olarak kullanımını araştırdık. Gereç ve Yöntemler: Toplam 457 kişi çalışmaya dahil edildi ve üç gruba ayrıldı. Birinci grup 197 kişiden oluşan kolesteatom grubu (n1 =197), ikinci grup 140 (n2=140) kişiden oluşan kolesteatomsuz kronik otitis media grubu ve üçüncü grup ise 120 (n3=120) kişiden oluşan kontrol grubudur. Çalışmanın verileri istatistiksel olarak değerlendirildi. Bulgular: Çalışmamızın sonuçları incelendiğinde; Ortalama Trombosit Hacmi (MPV) oranları, kolesteatom grubunda (n1) ortalama 10.009 ± 1.227, kolesteatomsuz kronik otitis media grubunda (n2) 10.302 ± 0.955 ve kontrol grubunda (n3) 10.492 ± 1.0531 olarak bulundu. Bu verilerin incelenmesi istatistiksel olarak anlamlı fark gösterdi. Çalışmamızda Nötrofil Lenfosit Oranları (NLR); kolesteatom grubunda (n1) 2.118 ± 1.040, kolesteatomsuz kronik otitis media grubunda (n2) 1.969 ± 2.125 ve kontrol grubunda (n3) 1.968 ± 1.549 olarak bulundu. Bu verilerin incelenmesi istatistiksel olarak anlamlı fark gösterdi. Çalışmamızda; kolesteatom grubunda, MPV ve NLR değerlerinin diğer iki gruptan istatiksel olarak anlamlı olduğu görüldü, ancak dahil edilen diğer parametreler arasında istatistiksel olarak anlamlı bir fark yoktu. Sonuç: Çalışmamızda; kolesteatomlu olguların, kronik aktif otitis mediadan ayrımında, MPV ve NLR değerlerinin anlamlı olduğunu gördük. Ancak literatür ile karşılaştırıldığında, NLR oranlarının kolesteatomlu olgularda daha güvenilir ve kullanışlı olduğunu tespit ettik.Öğe An unexpected complication after parotidectomy; severe bleeding due to systemic thrombolytic therapy for the treatment of pulmonary thromboembolism(2020) Aydın, Şükrü; Çiçek, Mehmet TuranPulmonary thromboembolism (PTE) is a serious cause of morbidity and mortality after surgery. Since most deaths occur within the first hour of patients, rapid thrombolytic treatment is lifesaving. In this article, a patient who was administered systemic thrombolytic therapy due to PTE after head and neck surgery was discussed. No additional prophylaxis was applied to the patient except for early ambulation. Since PTE has caused hemodynamic instability in the patient, systemic thrombolytics was administered, the PTE was successfully treated but a second surgical intervention was performed to control the bleeding from the surgical site. Systemic thrombolysis for treatment of PTE in otolaryngology surgery patients may be necessary but the morbidity of the bleeding in the surgical site should be considered.
