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Efficiency and side effects of isotretinoin usage in the treatment of acne vulgaris
(2008) Çikim A.Ç.; Seyhan M.
Background and Design: Although satisfying results with isotretinoin therapy were reported in treatment of severe or moderate but resistant acne vulgaris; the data about this treatment modality in Turkey is insufficient. Therefore we aimed to asses the clinical efficiency of isotretinoin treatment in patients with severe or moderate but resistant acne. Material and Method: Ninety four patients were enrolled into the study. The patients were evaluated for clinical symptoms and biochemical parameters; dosage of isotretinoin treatment; response to treatment and adverse events. Patients received 0,5-1 mg/kg/day isotretinoin for 24-32 weeks, with a 120/mg/kg total cumulative dose. The severity of the facial lesions were graded from 0 (no acne) to 12 (severe acne); and corporal lesions (back and chest) from 0 (no acne) to 8 (severe acne). Results: Although three of the patients (3.2%) failed to continue medication; ninety one patients (96.8%) finale the treatment period with complete recovery. The most common clinical side effect was cheilitis which was seen in all the patients and the most important biochemical side effect was the elevation of serum triglyceride concentrations. Conclusion: Isotretinoin can be concluded as a valuable and rather tolerable choice of treatment in patients with severe or moderate but resistant acne vulgaris.