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Öğe The effect of caffeic acid phenethyl ester CAPE against cholestatic liver injury in rats(J Surg Res, 0–0., 2010) Çoban, Sacid; Yıldız, Fahrettin; Alpaslan, Terzi; Al, Behcet; Özgör, Dinçer; Ara, Cengiz; Ara, Cengiz; Polat, Alaadin; Esrefoğlu, MukaddesObjectives. Caffeic acid phenethyl ester (CAPE) has been subjected to considerable investigations that have revealed its antioxidant and anti-inflammatory activities in different conditions. But there is not a previous investigation about its effect on cholestatic liver injury. The aim of this study was to investigate the effect of CAPE in rat liver against cholestatic liver injury induced by bile duct ligation. Methods. Swiss-albino rats were recruited in the study as follows; Group 1 rats subjected to simple laparotomy known as the sham group; Group 2 rats subjected to bile duct ligation (BDL); Group 3 bile duct ligated rats treated with CAPE. The third group received CAPE (10 mmol/kg) intraperitoneally daily throughout 14 d. Results. Data showed a decrease in g glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase levels (ALT) of the CAPE treated rats, compared with BDL group (P < 0.001, P < 0.01, and P < 0.02, respectively). In the CAPE treated rats, tissue levels of malondialdehyde (MDA) and myeloperoxidase (MPO) were significantly lower than that of the BDL group (P < 0.001). The levels of glutathione (GSH) in CAPE treated rats were significantly higher than that of BDL group (P < 0.001). In CAPE treated group, the levels of interleukin1alpha (IL-1a) and interleukin-6 (IL-6) were signifi- cantly lower than that of BDL group (P < 0.03, P < 0.02, respectively). Administration of CAPE in the rats with biliary obstruction resulted in inhibition of necro-inflammation. Conclusion. These results suggest that treatment of CAPE maintains antioxidant defenses, reduces oxidative liver injury, cytokine damage, and necroinflammation in bile duct ligated rats. Thus, CAPE seems to be a promising agent for the attenuation of cholestatic liver injury. 2010 Elsevier Inc. All rights reserved.Öğe Liver pathology and cell proliferation after calcineurin ınhibitors and antiproliferative drugs following partial hepatectomy in rats(Transplantation Proceedings, 38(2), 622–626., 2006) Kırımlıoğlu, Hale; Kırımlıoğlu, Vedat; Yılmaz, Sezai; Çoban, Sacid; Türkmen, Emine; Ara, CengizImmunosuppressants are the cornerstones of treatment after solid organ transplantation. This study investigated the pathology and cell proliferation following partial hepatectomy (PH) in rats undergoing immunosuppressive treatment. After 1 day, all rats were subjected to 70% PH. Groups A and B (n 10) received calcineurin inhibitors subcutaneously: either FK506 or cyclosporine (CyA). Groups C and D (n 10) received antiproliferative drugs: either mycophenolate mofetil (MMF) or sirolimus (SRL) by gavage. A control group (n 5) received 1 mL of tap water daily. On postoperative day 2, all rats were sacrificed to obtain liver tissue for pathologic examination. Using immunohistochemistry we separately examined the hepatectomy surface and the liver parenchyma. In the parenchyma, the Ki-67 indices were higher in the CyA and FK506 groups and lower in the SRL and MMF groups compared with controls (P .01). CyA had the highest and MMF the lowest values. On the hepatectomy surface, Ki-67 indices and TGF-alpha expressions were higher in the CyA group and lower in the SRL and MMF groups compared with the control group (P .01). Slightly higher values in the FK506 group were not significantly different compared with the control group (P .05). All groups other than FK506 showed prominent cholangiolar epithelial phenotypes compared with the control group. In the CyA and SRL groups, the number of cholangiolar cells was higher (P .01), and in the MMF group lower than in the control group (P .01). Among all groups, SRL had the highest values.Öğe Pankreas başına lokalize ve olagandan daha büyük insulinomalar: olgu sunumu(Tıp Araştırmaları Dergisi, 2009) Çoban, Sacid; Terzi, Alpaslan; Yıldız, Fahrettin; Özgör, Dinçer; Ara, Cengiz; Yılmaz, Sezai; Özdoğan, Mustafa KemalÖz: İnsülinoma pankreas adacık hücre tümörlerinin %70-75 ini teşkil eder (1). İnsülinomaların %80’i benign, 10’u malign olup %4-10’u multipl endokrin neoplazi tip I (MEN I) sendromu ile birlikte görülür (2, 3). Çoğunluğu 2 cm’den küçük ve soliter olduğundan (2, 4) uygulanan cerrahi yöntemler kolay ve küratif olmaktadır. Nadir görülen malign insülinomalar daha büyük çapta olma eğilimindedirler (5). Bu olgularda, özellikle pankreas başına lokalize büyük çaplı veya multipl insülinomalarda morbidite ve mortaliteyi arrtırabilen geniş rezeksiyonlar gerekebilir. Bu çalışmada ikisi pankreas başına lokalize ve büyük çaplı üç insülinoma olgusunu sunmayı amaçladık.Öğe Protective effect of resveratrol against renal oxidative stress in cholestasi(Ren Fail. 2005;27(4):435-40., 2005) Ara, Cengiz; Karabulut, Aysun Bay; Çoban, Sacid; Uğraş, Murat Yahya; Kırımlıoğlu, Vedat; Yılmaz, SezaiBACKGROUND/AIMS: This experimental study was designed to evaluate histological changes of the kidney and renal tissue levels of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) and the effect of resveratrol on these metabolites after bile duct ligation in rats. METHODS: Secondary biliary cirrhosis was induced by bile duct ligation for 28 days. Swiss albino rats were divided into three groups. Group 1: Sham (n=7), Group 2: Bile duct ligation (n=7), Group 3: Bile duct ligation plus resveratrol (n=7). Bile duct ligation (BDL) plus resveratrol group received 10 mgr/kg dose of resveratrol intraperitoneally daily throughout 28 days. Kidney tissues were harvested to determine the tissue levels of MDA, GSH, and NO activity. Liver and kidney tissues were removed for light microscopic evaluation. RESULTS: Cholestasis was determined by biochemical and pathologic examination. In the resveratrol-treated rats, levels of MDA were significantly lower than those of the BDL group (p < 0.04). The levels of GSH in the resveratrol-treated rats were significantly higher than those in the BDL group (p < 0.01). The levels of NO in the resveratrol group were significantly lower than those in the BDL group (p < 0.01). CONCLUSION: The present study demonstrates that intraperitoneal administration of resveratrol in bile duct ligated rats maintains antioxidant defenses and reduces kidney oxidative damage. This effect of resveratrol may be useful in the preservation of renal oxidative stress in cholestasis.Öğe Retroperitoneal hydatid disease(Gaziantep Tıp Dergisi, 2009) Çoban, Sacid; Kahraman, Latif; Özgör, Dinçer; Ara, CengizÖz: Hidatid hastalığın retroperitoneal lokalizasyonu oldukça nadirdir. Tanısı cerrahiden önce konulan, primer olarak retroperitoneald yerleşimli olan bir hidatid kist vakasını tanımladık. Retroperitonealdeki kistik kütlenin tanısında, kesin cerrahi strateji planı için ince bir iğne aspirasyon biyopsisi faydalıdır.Öğe Small bowel perforation after drawing a blood sample in the femoral artery a case report(Ulus Travma Acil Cerrahi Derg 2010;16 (3):275-276., 2010) Ara, Cengiz; Çoban, Sacid; Işık, Burak; Özcan, Canan Ceran; Yılmaz, SezaiSmall bowel perforation is a rare complication of femoral artery access in cases of femoral hernia. A 48-yearold woman was admitted to the intensive care unit due to pulmonary insufficiency. After a routine femoral arterial blood gas analysis, severe abdominal pain and nausea began. She underwent emergency laparotomy due to acute abdomen. Laparotomy revealed small bowel perforation. Segmental resection and end-to-end anastomosis were performed. The femoral canal was closed using plaque mesh. Special attention is needed during femoral artery access to avoid accidental small bowel perforation. As seen in this case, a careful examination should be done in cases of femoral hernia.Öğe Small bowel perforation afterdrawing a blood sample in the femoral artery a case report(Ulus Travma AcilCerrahi Dergisi, 2010) Ara, Cengiz; Çoban, Sacid; Işık, Burak; Özcan, Canan Ceran; Yılmaz, SezaiSmall bowel perforation is a rare complication of femoral artery access in cases of femoral hernia. A 48-yearold woman was admitted to the intensive care unit due to pulmonary insufficiency. After a routine femoral arterial blood gas analysis, severe abdominal pain and nausea began. She underwent emergency laparotomy due to acute abdomen. Laparotomy revealed small bowel perforation. Segmental resection and end-to-end anastomosis were performed. The femoral canal was closed using plaque mesh. Special attention is needed during femoral artery access to avoid accidental small bowel perforation. As seen in this case, a careful examination should be done in cases of femoral hernia.Öğe Spontaneous ıntestinal perforation due to non hodgkin s lymphoma evaluation of eight cases(Digestive Diseases and Sciences, 52(8), 1752–1756., 2007) Ara, Cengiz; Çoban, Sacid; Kayaalp, Cüneyt; Yılmaz, Sezai; Kırımlıoğlu, VedatAbstract Primary intestinal lymphoma with spontaneous perforation and after systemic chemotherapy is rare. The present study summarizes retrospectively the outcome of eight free intestinal perforated patients diagnosed with intestinal non-Hodgkin’s lymphoma. Two patients had a history of systemic chemotherapy before perforation. The most common symptoms of the patients were abdominal pain, nausea, vomiting, weight loss, and fever. Sites of perforation were ileum in four, jejunum in two, cecum in one, and sigmoid colon in one patient. Synchronous lymphoma was present in three patients. The perforation was closed by primary closure in three patients. Resection/anastomosis was performed in four patients and sigmoid colostomy was performed in one patient. Three patients were lost due to leakage or septicemia. Intestinal lymphoma might be kept in mind as a cause in free intestinal perforations. Because of the high mortality rate early diagnosis and treatment are important to improve the prognosis of bowel perforation in patients with non-Hodgkin’s lymphoma.Öğe Transabdominal approach in the surgical management of morgagni hernia(Surgery Today, 2006) Yılmaz, Mehmet; Işık, Burak; Çoban, Sacid; Söğütlü, Gökhan; Ara, Cengiz; Kırımlıoğlu, Vedat; Yılmaz, SezaiPurpose. Morgagni hernias are uncommon diaphragmatic hernias that are generally asymptomatic, and so far only limited data have been reported. The objective of this retrospective study was to evaluate the outcome of patients presenting with a complicated Morgagni hernia and who undergo a transabdominal repair. Methods. Between September 1999 and October 2005, 11 patients with Morgagni hernia were operated on in our department. Eight of them had acute presentations because of a complicated Morgagni hernia. The patient demographics, presenting symptoms, operative approach, and complications were collected. The postoperative course was evaluated for morbidity and mortality. Results. The patients’ ages ranged from 42 to 85 years (mean 69.4). Two (18.2%) patients were male and nine (81.8%) patients were female. Chest roentgenograms, computed tomography, and contrast meal studies were used as diagnostic utilities. A transabdominal approach was used for all patients. One patient died due to pulmonary failure. The mean follow-up was 2.8 years. There was no recurrence or symptoms regarding the operation in the remaining patients. Conclusion. We recommend the transabdominal approach in patients with Morgagni hernia as it makes it easy to reduce the hernia contents and repair of the hernia sac. Moreover, when complicated with strangulation, incarceration or perforation, a surgical repair through a transabdominal approach is mandatory.
