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    Analysis of the association between hand preference incidence in young healthy individuals and gender dominant eye 2D 4D ratio and hand grip strength
    (Azerbaijan Medical Association Journal, 2016) Çay, Mahmut; Şenol, Deniz; Çuğlan, Songül; Köse, Evren; Özbağ, Davut
    Objective: The purpose of this study is to examine the association between hand preference in young healthy individuals and handgrip strength (HGS), (which is accepted to be an objective measurement in the assessment of gender), 2D:4D ratio (ratio of the length of index finger to that of ring finger), eye dominance and upper limb performance. Methods: A total of 198 individuals, 111 males and 87 females, participated in our study. Oldfield Inventory was used to find out hand preference. Baseline hand dynamometer was used to find out HGS. The test developed by Rosenbach was used for determination of the dominant eye. For assessment of 2D:4D ratio, measurement was made starting from the basal fold of the finger to the fingertip. Results: According to the results of the statistical analysis, no significant difference was found between hand preference and 2D:4D (p>0.05). Statistically significant difference was found between eye dominance and hand preference (p<0.05). Statistically significant difference was found between right and left hand preference and right and left HGS of males (p<0.05). Statistically significant difference was found between right hand preference and right and left HGS of females (p<0.05), where significant difference was not found between left hand preference and right and left HGS of females (p>0.05). Conclusions: The association of hand preference with other parameters is important to determine cerebral lateralization. We believe that the result which shows hand preference was directly proportional to eye dominance and HGS means that these parameters can be a guide in determining the dominant hemisphere.
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    Corona mortis in vivo anatomical knowledge and the risk of injury in totally extraperitoneal inguinal hernia repair
    (Hernia, 2015) Ateş, Mustafa; Kınacı, Erdem; Köse, Evren; Soyer, Vural; Sarıcı, Kemal Barış; Çuğlan, Songül; Korkmaz, Mehmet Fatih; Dirican, Abuzer
    Purpose Corona mortis (CMOR) is the arterial and/or venous vascular communication(s) between the obturator and external iliac vessels. Totally extraperitoneal (TEP) inguinal hernioplasty can be associated with vascular complications especially during the fixation of the mesh. Theoretically, CMOR is an important nominee. But, the data in literature are insufficient about CMOR injury. Additionally, most of the studies about CMOR have been usually performed on cadavers. We aimed to reveal the preperitoneal vascular anatomy of inguinal area and provide in vivo knowledge about CMOR. The risk of arterial injury was also evaluated. Materials The data of preperitoneal vascular anatomy of 321 patients who underwent TEP procedure between January 2005 and July 2014 were retrospectively evaluated. Results Mean age was 46 ± 8.9 years, 53 females vs 268 males. 391 hemipelvises were evaluated. Two types of arterial structure were identified; (1) an aberrant obturator artery forming an anastomosis with branches of ordinary obturator artery; (2) a pubic branch of inferior epigastric artery. The incidence of arterial CMOR was 28.4 % and of any arterial structure was 45.0 %. An arterial CMOR was considered as thick (C2 mm) or thin (\2 mm). Injury of arterial CMOR during tack stapling on Cooper’s ligament was seen in six cases (1.5 %). All of them were thin (\2 mm) in structure. Venous CMOR was visible only under low pressure in work space. Conclusion During TEP hernia repair, CMOR and/or pubic branch of inferior epigastric artery can be damaged. To prevent this complication, tacks should be stapled to Cooper’s ligament close to symphysis pubis and dissection should be careful on the posterior surface of superior pubic ramus. Small caliber (\2 mm) arterial CMOR is more prone to be injured during TEP procedure. To explore venous structures properly, pressure in workspace should be kept as low as possible.
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    Gebe ratlarda formaldehit maruziyetinin fetusların morfolojik yapıları ile karaciğer dokusunun gelişimi üzerine zararlı etkilerinin araştırılması; chrysin'in muhtemel koruyucu rolünün incelenmesi
    (İnönü Üniversitesi, 2012) Çuğlan, Songül
    Deneysel olan bu çalışmada, gebelikte formaldehit maruziyetinin fetusların morfolojisi ve karaciğer gelişimi üzerindeki olası zararlı etkilerinin incelenmesi ve olası bu zararlı etkilere yönelik chrysin'in muhtemel koruyucu etkisinin belirlenmesi amaçlandı. Gereç ve Yöntem: Çalışmada ağırlıkları 200-250 gr arasında olan, erişkin 67 adet Wistar Albino cinsi dişi sıçan kullanıldı. 67 adet dişi sıçan 7 gruba ayrıldıktan sonra gebelik oluşturulmaya çalışıldı. Gebe kalmayan 12 dişi sıçan deney dışı bırakıldı. Grup I'e intraperitoneal (i.p.) serum fizyolojik, Grup II'ye gavaj yolu ile 20 mg/kg chrysin (CH), Grup III'e i.p. yolla 0,1 mg/kg formaldehit (FA), Grup IV'e i.p. yolla 1 mg/kg FA, Grup V'e i.p. yolla 0,1 mg/kg FA ve gavaj yolu ile 20 mg/kg CH, Grup VI'ya i.p. yolla 1 mg/kg FA ve gavaj yolu ile 20 mg/kg CH ve Grup VII'ye gavaj yolu ile mısır yağı gebeliğin 7.-20. günleri arası gün aşırı uygulandı. Gebeliğin 20. günü sezeryan yapılarak fetuslar çıkarıldı. Fetusların morfolojik parametreleri (fetus ağırlığı ve karaciğer ağırlığı) incelendi. Karaciğer gelişimindeki etkilenmeyi belirlemek için histolojik boyamalar (Hematoksilen-Eozin ve Periyodik Asit-Schiff) ve biyokimyasal analizler yapıldı. Bulgular: FA uygulanan grupların fetus ağırlığı ve karaciğer ağırlığında istatistiksel olarak anlamlı bir şekilde azalma saptandı. Fetus karaciğerinde hem 0,1 mg/kg FA hem de 1 mg/kg FA grubunda megakaryosit sayısında istatistiksel olarak anlamlı bir azalma tespit edildi. 1 mg/kg FA grubunda ise histopatolojik değişiklikler gözlendi. Biyokimyasal olarak FA, glutatyon (GSH) düzeyini azalttı ve malondialdehit (MDA) düzeyini arttırdı. Sonuç: Gebelikte düşük doz FA maruziyeti, oksidatif stres oluşturmak suretiyle fetusun morfolojik, histolojik ve biyokimyasal olarak olumsuz etkilenmesine sebep olur. CH ise morfolojik ve biyokimyasal parametrelerde antioksidan etki göstermekte ama histopatolojik değişiklikleri düzeltmekte yetersiz kalmaktadır. Anahtar Kelimeler: Formaldehit, Chrysin, Rat fetus, Morfolojik yapı, Karaciğer gelişimi. Gereç ve Yöntem: Çalışmada ağırlıkları 200-250 gr arasında olan, erişkin 67 adet Wistar Albino cinsi dişi sıçan kullanıldı. 67 adet dişi sıçan 7 gruba ayrıldıktan sonra gebelik oluşturulmaya çalışıldı. Gebe kalmayan 12 dişi sıçan deney dışı bırakıldı. Grup I'e intraperitoneal (i.p.) serum fizyolojik, Grup II'ye gavaj yolu ile 20 mg/kg chrysin (CH), Grup III'e i.p. yolla 0,1 mg/kg formaldehit (FA), Grup IV'e i.p. yolla 1 mg/kg FA, Grup V'e i.p. yolla 0,1 mg/kg FA ve gavaj yolu ile 20 mg/kg CH, Grup VI'ya i.p. yolla 1 mg/kg FA ve gavaj yolu ile 20 mg/kg CH ve Grup VII'ye gavaj yolu ile mısır yağı gebeliğin 7.-20. günleri arası gün aşırı uygulandı. Gebeliğin 20. günü sezeryan yapılarak fetuslar çıkarıldı. Fetusların morfolojik parametreleri (fetus ağırlığı ve karaciğer ağırlığı) incelendi. Karaciğer gelişimindeki etkilenmeyi belirlemek için histolojik boyamalar (Hematoksilen-Eozin ve Periyodik Asit-Schiff) ve biyokimyasal analizler yapıldı. Bulgular: FA uygulanan grupların fetus ağırlığı ve karaciğer ağırlığında istatistiksel olarak anlamlı bir şekilde azalma saptandı. Fetus karaciğerinde hem 0,1 mg/kg FA hem de 1 mg/kg FA grubunda megakaryosit sayısında istatistiksel olarak anlamlı bir azalma tespit edildi. 1 mg/kg FA grubunda ise histopatolojik değişiklikler gözlendi. Biyokimyasal olarak FA, glutatyon (GSH) düzeyini azalttı ve malondialdehit (MDA) düzeyini arttırdı. Sonuç: Gebelikte düşük doz FA maruziyeti, oksidatif stres oluşturmak suretiyle fetusun morfolojik, histolojik ve biyokimyasal olarak olumsuz etkilenmesine sebep olur. CH ise morfolojik ve biyokimyasal parametrelerde antioksidan etki göstermekte ama histopatolojik değişiklikleri düzeltmekte yetersiz kalmaktadır.
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    Kimmerle s anomaly posterior osseous bridging of atlas
    (Medicine Science | International Medical Journal, 2015) Şenol, Deniz; Canpolat, Mustafa; Ulutaş, Nihal Sümeyye; Çay, Mahmut; Çuğlan, Songül; Köse, Evren; Özbağ, Davut
    Kimmerle’s anomaly is a rare and serious pathology of the 1st cervical vertebra, which may sometimes lead to hardly explicable changes in vertebrobasilar circulation. Also known as ponticulus posticus (PP), this phenomenon encircles the vertebral artery and suboccipital nerve and is associated with vertigo, vertebro-basilar insufficiency, neck pain, shoulder pain and cervicogenic headache symptoms. It can also lead to migraine as a result of its interaction with dura. As the knowledge of this variant by clinicians is important for obtaining a fast result in the treatment, it should also be taken into account in surgical approaches so as not to harm the vessels and nerves in this area.
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    Rapid detection of bloodstream pathogens in liver transplantation patients with filmarray multiplex polymerase chain reaction assays comparison with conventional methods
    (Transplantation Proceedings, 2015) Otlu, Barış; Bayındır, Yaşar; Özdemir, Fatih; İnce, Volkan; Çuğlan, Songül; Hopoğlu, Murat; Yakupoğulları, Yusuf; Kızılkaya, Cana; Kuzucu, Çiğdem; Işık, Burak; Yılmaz, Sezai
    Background. Bloodstream infection (BSI) is an important concern in transplant patients. Early intervention with appropriate antimicrobial therapy is critical to better clinical outcome; however, there is significant delay when conventional identification methods are used. Methods. We aimed to determine the diagnostic performance of the FilmArray BloodCulture Identification Panel, a recently approved multiplex polymerase chain reaction assay detecting 24 BSI pathogens and 3 resistance genes, in comparison with the performances of conventional identification methods in liver transplant (LT) patients. A total of 52 defined sepsis episodes (signal-positive by blood culture systems) from 45 LT patients were prospectively studied. Results. The FilmArray successfully identified 37 of 39 (94.8%) bacterial and 3 of 3 (100%) yeast pathogens in a total of 42 samples with microbial growth, failing to detect only 2 of 39 (5.1%) bacterial pathogens that were not covered by the test panel. The FilmArray could also detect additional pathogens in 3 samples that had been reported as having monomicrobial growth, and it could detect Acinetobacter baumannii in 2 samples suspected of skin flora contamination. The remaining 8 blood cultures showing a positive signal but yielding no growth were also negative by this assay. Results of MecA, KPC, and VanA/B gene detection were in high accordance. The FilmArray produced results with significantly shorter turnaround times (1.33 versus 36.2, 23.6, and 19.5 h; P < .05) than standard identification methods, Vitek II, and Vitek MS, respectively. Conclusions. This study showed that the FilmArray appeared as a reliable alternative diagnostic method with the potential to mitigate problems with protracted diagnosis of the BSI pathogens in LT patients.
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    The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development
    (Medicine Science | International Medical Journal, 2016) Çuğlan, Songül; Ekinci, Nihat; Yıldız, Azibe; Doğan, Zümrüt; Sapmaz, Hilal Irmak; Vardı, Nigar; Özyalın, Fatma; Bakırcı, Sinan; Çay, Mahmut; Köse, Evren; Türköz, Yusuf; Özbağ, Davut
    This study was aimed to investigate possible harmful effects of formaldehyde (FA) exposure on the morphology of fetus liver and kidney development during pregnancy and also to determinate possible protective role of chrysin (CH) against these harmful effects. For this aim, after pregnancy was induced, 58 female rats were divided into 6 groups. Serum physiologic (SF) was injected to the Group I rats intraperitoneally (i.p.). 20 mg/kg CH was given to the Group II via gavage. 0.1 mg/kg FA was applied to the Group III (i.p.), 1 mg/kg FA was injected to Group IV (i.p.) 0.1 mg/kg FA was given to Group V i.p., and 20 mg/kg CH was given to the same group via gavage. 1 mg/kg FA was applied to Group VI i.p., and 20 mg/kg CH was given to the same group via gavage. Fetuses were taken from each pregnant rat with cesarean section on the 20th day of the pregnancy. The morphological analyses of the fetuses, liver and kidney; biochemical and histological analyses of the liver and kidney were performed. The fetal body, liver and kidney weight of the FA groups demonstrated a statistically significant decrease the compared to control group. Also the FA-1 group were observed histopathological changes on the fetus liver and kidneys. FA exposure causes harmful effects on fetus the liver and kidneys. CH reduces the negative effect on morphological variables statistically. Although CH is insufficient to fix the histopathological changes that occur in the liver, damaging effects that occur in the kidney decreased statistically.
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    Variation of axillopectoral muscle and surgical importance: a case report
    (Turgut Özal Tıp Merkezi Dergisi, 2016) Cay, Mahmut; Çuğlan, Songül; Şenol, Deniz; Özbağ, Davut; Köse, Evren
    Abstract M. axillopectoralis (MAP) has been examined under different names and variations in different studies. In routinely conducted dissection studies, an arch holding onto great pectoral muscle originating from latissimus dorsi muscle was detected in the left fossa axillaris of a male cadaver aged 35-40. It was determined that the end branches of a. axillaris, v. axillaris, and plexus brachialis existing in that area passed through the underneath of that arch. MAP has a clinical and morphological importance for those surgeons that are to make surgical interventions in the fossa axillaris area. Thus, surgeons are required to consider the probability of such muscle structures in this area. Keywords: Fossa Axillaris; Variation; Latissimus Dorsi Muscle; MAP; Cadaver.