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    Effects of Tadalafi l on Macular Parameters and Choroidal Thickness in Diabetic Patients
    (Retina-Vitreus, 2018) Özer, Murat Atabey; Özen, Serkan; Polat, Nihat; Öğreden, Ercan; Demirelli, Erhan; Beytur, Ali; Küçüksümer, Yaşar
    Öz: Objective: To investigate the effects of tadalafi l on macular parameters and choroidal thickness in diabetic patients with erectile dysfunction (ED). Materials and methods: Total 37 diabetic patients with ED were included in this single-centred, open-label prospective study. The treatment was initiated with 5 mg tadalafi l hydrochloride daily for 3 months. Choroidal thickness, central macular thickness (CMT), and total macular volume (TMV) measurements were performed using spectral domain optical coherence tomography (SD-OCT). SD-OCT and visual acuity (VA) measurements were repeated during all visits. Fundus fl uorescein angiography (FFA) was also performed at baseline and at the 12 th week. Results: There was a statistically signifi cant increase in the choroidal thickness compared to that at baseline at all visits except at the fi rst visit (mean central foveal choroidal thickness, baseline; 248.7 ± 21.5, 1 st day; 247.4 ± 23.2, 4 th week; 275.9 ± 21.3, and 12 th week; 275.1 ± 24.4, ?m, p < 0.001). There was no statistically signifi cant change in the mean VA (baseline; 0.21 ± 0.07, 12 th week; 0.22 ± 0.06, logMar), mean CMT (baseline; 236.7 ± 32.4, 12 th week; 234.8 ± 32.8, ?m), mean TMV (baseline; 9.88 ± 1.21, 12 th week; 9.83 ± 1.26, mm 3 ), and FFA compared to the baseline values (p > 0.05). Conclusions: Choroidal thickness safely increases in response to systemic tadalafi l administration. The long-term use of systemic tadalafi l does not cause any adverse effects on the retina and the macula in diabetic patients with ED.