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Öğe Assessment of novel biomarkers: STREM-1, pentraxin-3 and pro-adrenomedullin in the early diagnosis of neonatal early onset sepsis(IOS Press, 2020) Tunç T.; Polat A.; Özdemir R.; Kiliçaslan B.; Can E.; Çelik H.T.; Arsan S.BACKGROUND: Early onset bacterial sepsis in neonates (EOS) is recognized as an important health condition. Early diagnosis is crucial. However, blood culture results are released in 48-72 hours. Many biomarkers have been investigated but none have been accepted as the gold standard. This study aimed to investigate the diagnostic value of the molecules: soluble form of triggering receptor expressed on myeloid cells-1 (sTREM-1), pentraxin-3 (PTX-3) and pro adrenomedullin (pro-ADM) in EOS and compare with currently used biomarkers. METHODS: In this multicenter prospective study, patients were enrolled from different NICUs around the Turkey. Patient data were collected via web-based registry system from attending centers. Neonates, hospitalized with a suspicion of EOS were enrolled. Blood culture and routine blood tests were collected and a serum sample was obtained and kept in-80°C for studying the molecules. According to laboratory results, patients were divided into three groups as; proven sepsis, clinical sepsis and control group. Groups were compared in terms of demographic, clinical and laboratory findings. The primary outcome of the study was to assess any difference between groups in terms of the diagnostic value of the markers aforementioned. RESULTS: A total of 130 patients were enrolled; proven sepsis (n = 36), clinical sepsis (n = 53) and control (n = 41) groups. Groups were similar in terms of demographic findings; mean WBC (P = 0.445), procalcitonin (PCT) (P = 0.083) and IL-6 (P = 0.814) levels. Mean C-reactive protein (CRP) level was significantly higher in clinical sepsis and proven sepsis groups compared to control group (P < 0.001). Mean PTX-3 (P = 0.547), pro-ADM (P = 0.766) and sTREM-1 (P = 0.838) levels were similar between groups. CONCLUSION: These promising molecules failed to help in early diagnosis of EOS. Their relation to correlation with disease progression may make more sense as they seem to be expressed in higher amounts with the progression of the disease in previous studies. CRP was the most frequently used biomarker for detecting the sepsis in our study population. © 2020-IOS Press and the authors. All rights reserved.Öğe The effect of massage, wipe bathing and tub bathing on physiological measurements of late premature newborns: A randomized controlled trial(Elsevier Ltd, 2022) Suna Dağ Y.; Yayan E.H.; Özdemir R.Objective: The aim of this randomized experimental study is to analyze the effect of massage, wipe bathing and tub bathing on physiological measurements of late premature newborns. Design: and Methods: This randomized experimental study was conducted on 192 newborns at the gestational week of 34 or higher in the neonatal intensive care unit of a university hospital. The researchers applied massage (n: 48), tub bathing (n: 48), and wipe bathing (n: 48) to the newborns. The control group (n: 48) received no intervention except for the routine clinical practices. The newborns' physiological measurements before, immediately after and 30 min after the interventions were taken and recorded on the “Newborn Follow-up Form.” The newborns’ physiological measurements were assessed by independent evaluators who were blinded to the purpose of the study at different phases across the massage, wipe bathing and tub bathing protocols. The statistical analysis was performed using percentages, means, repeated analysis, variance analysis, Bonferroni analysis. Results: No difference was found in the massage, wipe bathing, tub bathing and control groups' mean physiological measurements (pulse, respiration, oxygen saturation, blood pressure, body temperature) (p > 0.05). © 2021Öğe Neonatal cholestasis: Retrospective analysis of 94 cases(Cocuk Sagligi ve Hastaliklan Dergisi, 2017) Bıçakcıoğlu I.; Özdemir R.; Turgut H.; Gökçe I.K.; Selimoğlu M.A.Neonatal cholestasis is a condition that begins in the neonatal period due to intrahepatic and the extrahepatic causes. The objective of our study was to evaluate the ethiological factors, symptoms and physical examination findings, laboratory results and follow up results for cases with neonatal cholastasis and to compare this data with those of other studies. Neonatal cholestasis cases that were diagnosed between 2009-2014 in Neonatal Care Unit were included in this study. The diagnoses, physical examinations, clinical courses and the prognoses were retrospectively evaluated in two groups; younger than 32 weeks (Group 1) and older than 32 weeks (Group 2). 94 newborns were found to have neonatal cholestasis. Patients in Group 2 (n= 60) had earlier neonatal cholestasis (p=0.001). The most common complaints of the patients and/or physical examination findings were jaundice. The most common etiologic factors involved in the etiology of neonatal cholestasis were TPN associated cholestasis (n= 21). No etiology was defiend in 13 patients. It was observed that 33 (35%) of the patients died during the follow-up. We consider that the early diagnosis is important; during the search of the etiological cause, the features such as the gestational age and the birth weight of the patient should be taken into consideration and we also consider that when the extrahepatic causes are relevant, the surgical treatment should not be delayed. © 2018 Cocuk Sagligi ve Hastaliklan Dergisi. All rights reserved.Öğe RE: Mean platelet volume in patients with idiopathic and ischemic cardiomyopathy(2013) Açikgöz N.; Ermiş N.; Ya?mur J.; Cansel M.; Ataş H.; Pekdemir H.; Özdemir R.[No abstract available]
