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  • Küçük Resim
    Öğe
    Effects of molsidomine on retinopathy and oxidative stress Induced by radiotheraphy in rat eyes
    (Current Eye Research, 2016) Özer, Murat Atabey; Polat, Nihat; Özen, Serkan; Ekici, Kemal; Polat, Alaaddin; Vardı, Nigar; Tanbek, Kevser; Yıldız, Azibe; Parlakpınar, Hakan
    Purpose: To determine the role of Molsidomine in preventing radiation-induced retinopathy after head and neck region irradiation of rats with a single radiation dose of 15 Gy. Male Wistar albino rats were randomly grouped into five as follows: (1) control group rats, which were applied through an intraperitoneal (i.p.) vehicle without radiotherapy (RT); (2) RT group rats received a single dose of 15 Gy irradiation and after daily 0.1 ml vehicle i.p. for 5 consecutive days; (3) molsidomine (MOL) group rats were treated for 5 consecutive days by i.p. with 4 mg/kg/day MOL; (4) irradiation plus MOL group (RT+MOL) rats received irradiation and after 10 days single daily i.p. dose of MOL for 5 consecutive days; and (5) MOL+RT group rats were treated for 5 consecutive days by i.p. with MOL before RT. At the end of the work the rats were sacrificed under high-dose anesthesia on the 16th day and then eye tissues were taken for histopathological, immunohistochemical (caspase-3), and biochemical analyses (superoxide dismutase [SOD], glutathione peroxidase [GSH], and malondialdehyde [MDA]). RT significantly decreased both the content of GSH and the activity of SOD, and significantly increased the production of MDA level in the rat eyes. MOL treatment significantly increased the SOD and GSH levels and significantly decreased the MDA production (p < 0.0001). In addition, RT significantly increased the number of ganglion cells (GCs; p = 0.001), whereas especially pretreatment with MOL improved (p = 0.013). RT led to significant retinopathy formation, and MOL therapy protected the retina from radiation-induced retinopathy (p < 0.0001). We suggest that MOL is a powerful antioxidant and free radical scavenger that prevents the rat eyes from radiation-induced retinopathy and oxidative stress.
  • Küçük Resim Yok
    Öğe
    Effects of Tadalafi l on Macular Parameters and Choroidal Thickness in Diabetic Patients
    (Retina-Vitreus, 2018) Özer, Murat Atabey; Özen, Serkan; Polat, Nihat; Öğreden, Ercan; Demirelli, Erhan; Beytur, Ali; Küçüksümer, Yaşar
    Öz: Objective: To investigate the effects of tadalafi l on macular parameters and choroidal thickness in diabetic patients with erectile dysfunction (ED). Materials and methods: Total 37 diabetic patients with ED were included in this single-centred, open-label prospective study. The treatment was initiated with 5 mg tadalafi l hydrochloride daily for 3 months. Choroidal thickness, central macular thickness (CMT), and total macular volume (TMV) measurements were performed using spectral domain optical coherence tomography (SD-OCT). SD-OCT and visual acuity (VA) measurements were repeated during all visits. Fundus fl uorescein angiography (FFA) was also performed at baseline and at the 12 th week. Results: There was a statistically signifi cant increase in the choroidal thickness compared to that at baseline at all visits except at the fi rst visit (mean central foveal choroidal thickness, baseline; 248.7 ± 21.5, 1 st day; 247.4 ± 23.2, 4 th week; 275.9 ± 21.3, and 12 th week; 275.1 ± 24.4, ?m, p < 0.001). There was no statistically signifi cant change in the mean VA (baseline; 0.21 ± 0.07, 12 th week; 0.22 ± 0.06, logMar), mean CMT (baseline; 236.7 ± 32.4, 12 th week; 234.8 ± 32.8, ?m), mean TMV (baseline; 9.88 ± 1.21, 12 th week; 9.83 ± 1.26, mm 3 ), and FFA compared to the baseline values (p > 0.05). Conclusions: Choroidal thickness safely increases in response to systemic tadalafi l administration. The long-term use of systemic tadalafi l does not cause any adverse effects on the retina and the macula in diabetic patients with ED.