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    The effect of demographic, biochemical and patholojical parameters on survival in colorectal cancer
    (Turgut Özal Tıp Merkezi Dergisi, 2016) Benek, Suat; Tatar, Cihad; Kocakusak, Ahmet; Özer, Bahri; Kızılkaya, Mehmet Celal; Aydın, Hüsnü
    Abstract Aim: Colorectal cancer is one of the most commonly encountered malign tumors. In this study we studied the patients who have been operated for colorectal cancer retrospectively, to determine the parameters if they are prognostic or not. Materials and Methods: 115 patients who had been operated on because of CRC were evaluated. Gender, age, place of tumor, local invasion, cancer history in first-degree relatives, chemotherapy history, histological grade, T stage, tumor size, total number of resected lymph nodes, metastatic lymph node number, positive lymph node ratio (PLNR),CEA, CA 19-9, albumin, CRP, survival, stage of disease were recorded and those parameters were compared with each other in two groups according to survival during follow-up. Results: There were not any statistically difference as regard to age, young patients, gender, tumor location and family history between two groups ( p=0,411 p=0,545 p=0,656 p=0.177 p=0,659). However, statistically significant parameters in patients who died during follow-up were histological grade, T stage, the number of metastatic lymph node, stage, PLNR, CEA, CA 19-9 and CRP (p=0.034 for CA 19-9 and p<0.001 for the remaining parameters). Histological grade and CRP were independent risk factors according to univariate analysis. Gender, age, and total numbers of the resected lymph nodes were parameters very near to significance. Conclusions: For the patients with colorectal cancer grade, T stage, metastatic lymph node, CEA, CA 19-9 and CRP were found to have poor prognostic values. Keywords: Cancer; Colorectal; Prognosis; Survival.