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Effect of risperidone on auditory event-related potentials in patients with chronic schizophrenia
(2005) Özişik H.I.; Özcan Y.; Kizkin S.; Ünal S.; Özcan C.
Objective: Cognitive deficits are major aspect and cause of disability in schizophrenia. Several neuropsychological studies have reported significant effects of atypical neuroleptics on cognitive functioning in patients with schizophrenia. Event-related potentials are objective assessments of human information processing, and provide a reliable method for evaluating the effects of psychotropic drugs. Methods: The study sample consisted of 7 subjects. They were outpatients at the Department of Psychiatry, İnönü University Hospital. The patients were diagnosed as having schizophrenia according to the DSM-IV on the basis of a structured psychiatric interview. The subjects were treated with risperidone. In order to examine the effects of risperidone on cognitive impairment in schizophrenia, event-related potentials (ERPs) were recorded before and after 6 weeks treatment ERPs were recorded using a standard oddball paradigm. The amplitudes and latencies of P300 component were measured in ERPs for target stimuli in the oddball task. Results: P300 latencies in Fz, Cz and Pz regions and amplitudes in Fz and Cz regions significantly decreased with risperidone treatment. Conclusion: These findings suggest that risperidone may speed up the information processing in schizophrenic patients.