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    The effect of impulse noise on the epithelial cells of the choroid plexus
    (Turkish Neurosurg, 2011) Aydın, Mehmet Dumlu; Üngören, Mehmet Kaan; Aydın, Nazan; Halıcı, Zekai; Önder, Arif; Gündoğdu, Cemal; İzci, Yusuf
    The aim of this study was to investigate the effects of impulse noise on the epithelial cells of the choroid plexus. MaterIal and Methods: Forty Sprague Dawley rats were used and divided into the 2 groups as control and study groups. In the control group, the rats did not suffer noise injury. The rats were exposed to impulse noise at 20 minute durations at 10 times each day for one month in study group. Then, the rats were sacrificed and the choroid plexuses were examined histologically. The number of cells was counted and the cells were analyzed. Results: There were clear signs of nuclear condensation and cell body shrinkage, suggesting the presence of apoptosis. Severe desquamation of villus and the cell loss were observed in the study group. The numbers of the normal cells decreased, and the number of apoptotic cells increased significantly (p<0.05). ConclusIon: Impulse noise causes apoptotic death of epithelial cells in the choroid plexus, decrease the normal cells and increase the apoptotic cells.
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    The role of trigeminal ganglion neuron density in the preventive of subarachnoid hemorrhage induced basilar artery vasospasm an experimental study
    (Neurosurgery Quarterly, 2009) Aydın, Mehmet Dumlu; Üngören, Mehmet Kaan; Aydın, Nazan; Halıcı, Zekai; Önder, Arif; Gündoğdu, Cemal; İzci, Yusuf
    Objective: Cerebral arteries innervated by several systems contribute to the control of cerebral blood flow. Sensory fibers of the trigeminal nerve have a vasodilatory effect on the basilar artery. Subarachnoid hemorrhage (SAH) causes severe cerebral vasospasm by various neurochemical mechanisms. We examined possible relationships between the neuron density of the trigeminal ganglion and the severity of basilar artery vasospasm in SAH. Methods: In this study, 28 rabbits were used. The animals were randomly divided into 3 groups: SAH (n=18), serum physiologic (n=5) and control (n=5) groups. Experimental SAH was induced by injecting homologous blood into the cisterna magna. After 20 days, the basilar arteries and trigeminal ganglions were examined histopathologically. Basilar artery volumes and the neuron density of the ophthalmic divisions of the trigeminal ganglions were estimated stereologically, and the results were statistically analyzed. Results: The mean basilar artery volume was 4.15±0.19 mm3 and the mean neuronal density of the trigeminal ganglion was 6500±750/mm3 for the control group. These values were 4.05±0.29 mm3 and 6400±584/mm3 for the serum physiologic group, 3.80±0.35 mm3 and 4600±300/mm3 for living animals in the SAH group, and 2.26±0.29 mm3 and 2950±618/mm3 for dead animals in SAH group, respectively. A linear relationship was found between the neuronal density of the trigeminal ganglion and basilar artery volumes. Conclusions: The neuron density of the trigeminal ganglion may be an important factor in the regulation of basilar artery volume and for the continuation of cerebral blood flow. The low neuron density of the trigeminal ganglion may be involved in the pathogenesis of severe basilar artery vasospasm induced by SAH. The Role of Trigeminal Ganglion Neuron Density in the Prevention of Subarachnoid Hemorrhage-induced Basilar Artery Vasospasm: An Experimental Study. Available from: https://www.researchgate.net/publication/232176472_The_Role_of_Trigeminal_Ganglion_Neuron_Density_in_the_Prevention_of_Subarachnoid_Hemorrhage-induced_Basilar_Artery_Vasospasm_An_Experimental_Study [accessed Jul 7, 2017].
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    Tethered cord syndrome: 5 year clinical experiences and surgical results
    (2018) İzci, Yusuf; Kural, Cahit; Ramikhanov, Zaur; Mehtiyev , Royal; Kacar, Yunus
    Abstract:Aim: Occult spinal dysraphism, which manifests with motor and sensory disturbances in children and causes orthopedic deformities in the lower extremities and urological findings, is the result of developmental defects in the caudal part of the neural tube. One of the most common spinal dysraphism is tethered cord syndrome (TCS). In this study, patients who had been diagnosed with TCS in the past 5 years were retrospectively reviewed and clinical, radiological and surgical characteristics of these patients were tried to be revealed. Material and Methods: We retrospectively reviewed the data about 26 patients with the diagnosis of TCS in our clinic between 2011- 2015. The results of these surgeries were evaluated by age, gender, additional malformations, clinic symptoms, radiological and electrophysiological evaluation. The patient with urological symptoms was additionally performed in urodynamic tests. Results: These 26 cases, 23% were children and 77% were adults. 81% of the patients were male and 19% female. Only 3.8% of the patients were primary TCS, 96.2% of the patients had other malformations. Urine incontinence was found in 19.2% of the patients and orthopedic deformities were found in 7.7% of the patients. Surgical treatment was done to 65% of the patients, and 35% of the patients were followed because they didn’t want to be operated. Conclusion: Tethered cord syndrome is usually not seem alone, it is associated with other developmental defects of the spine and spinal cord. If surgery done earlier, the greater the likelihood of regression of the neurological deficit or stablization the deficits.