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    Isolated CA 19-9 elevation as preceding finding of colorectal carcinoma
    (2016) Şahin, Abdurrahman; Bilgiç, Yılmaz; Cengiz, Mustafa; Altınsoy, Hasan Baki
    Abstract: Rectal bleeding, change in bowel habits, abdominal pain are cardinal symptoms of colorectal carcinoma. Otherwise, weight loss, fatigue and weakness do not suggest colorectal carcinoma. Carbohydrate antigen (CA) 19-9 level is higher in several malignancies, especially gastrointestinal malignancies, and some benign conditions. Herein, we present a patient who is referred to our clinic with the complaint of fatigue and significant CA 19-9 elevation, diagnosed as metastatic colorectal carcinoma. Presenting case highlights that CA 19-9 elevation might be the only finding of colorectal carcinoma in even patients with nonspecific complaints
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    The Relationship Between Hepatic Activity Index and Serum Tumor Necrosis Factor Alpha Levels in Patients with Chronic Active Hepatitis-B and Chronic Active Hepatitis-C
    (2015) Bilgiç, Yılmaz; Harputluoğlu, Muhsin Murat Muhip; Dal, Mehmet Burak; Bozan, Mehmet Buğra; Şahin, Abdurrahman; Yazar, Fatih Mehmet; Çağın, Yasir Furkan
    Abstract: In the present study, we investigated the relationship between serum TNF-? levels and hepatic activity in liver biopsies of chronic hepatitis B and C patients.The study was performed on 30 chronic hepatitis B patients, 25 chronic hepatitis C patients and 25 healthy controls. Serum samples of patients who underwent biopsy and healthy controls were collected. Control group was seronegative for hepatitis and had normal liver function tests. TNF- ? levels measured by ELISA. Knodell’s hepatic activity index was used in evaluation of liver biopsies. Serum TNF? levels were determined higher in chronic hepatitis B and C patients than control group. HAI and TNF- ? compared in chronic hepatitis B and C patients. Although we detected a relationship between HAI and TNF-? levels in chronic hepatitis B patients, no true correlation was shown in chronic hepatitis C patients. Cytokines have an important role in progression of chronic hepatitis B and C infections. There is a relationship between hepatic activity index and TNF-? level in chronic hepatitis B infection.But There is not relationship between hepatic activity index and chronic hepatitis C infection.only in two patients and both of them where in the middle of their reproductive age while as symptomatic ovarian cysts was a more common finding in unmarried females in 21-28 years of age group. This study concluded that laparoscopy has a diagnostic as well as a therapeutic implication in management of NSAP